Pharmacogenomics in Drug Discovery and Development

ISBN-13: 9781071625750 / Angielski / Miękka / 2023

Opis

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. 

Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Spis treści

1. Target Discovery for Drug Development Using Mendelian Randomization

            Daniel S. Evans

 

2. Human Leukocyte Antigen (HLA) Testing in Pharmacogenomics

            Ann M. Moyer and Manish J. Gandhi

 

3. Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer

            Zahra Talebi, Alex Sparreboom, and Susan I. Colace

 

4. Pharmacogenomics in Cytotoxic Chemotherapy of Cancer

            Zahra Talebi, Alex Sparreboom, and Susan I. Colace

 

5. Management of Side Effects in the Personalized Medicine Era: Chemotherapy-Induced Peripheral Neuropathy

            Eleonora Pozzi and Paola Alberti

 

6. The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine

            Qing Yan

 

7. Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next Generation Sequencing Data

            Begoña Alburquerque-González, María Dolores López-Abellán, Ginés Luengo-Gil, Silvia Montoro-García, and Pablo Conesa-Zamora

 

8. COVID-19 Pharmacotherapy: Drug Development, Repurposing of Drugs, and the Role of Pharmacogenomics

            Rebecca Bock, Mariana Babayeva, and Zvi G. Loewy

 

9. Pharmacogenomics Informs Cardiovascular Pharmacotherapy

            Mariana Babayeva, Brigitte Azzi, and Zvi G. Loewy

 

10. Pharmacogenomic Screening of Patient-Specific hiPSC-Derived Cardiomyocyte Drug Candidates Using High-Throughput Calcium Imaging

            Malorie Blancard, K. Ashley Fetterman, and Paul W. Burridge

 

11. The Yin-Yang Dynamics in Cardiovascular Pharmacogenomics and Personalized Medicine

            Qing Yan

 

12. GTPgS Assay for Measuring Agonist-Induced Desensitization of Two Human Polymorphic Alpha_2B-Adrenoceptor Variants

            Jordana I. Borges, Alexandra M. Carbone, Natalie Cora, Anastasiya Sizova, and Anastasios Lymperopoulos

 

13. Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development

            Ramón Cacabelos, Vinogran Naidoo, Olaia Martínez-Iglesias, Lola Corzo, Natalia Cacabelos, Rocío Pego, and Juan C. Carril

 

14. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia

            Samar S.M. Elsheikh, Daniel J. Müller, and Jennie G. Pouget

 

15. The Pharmacogenetic Impact on the Pharmacokinetics of ADHD Medications

            Jacob T. Brown

 

16. Pharmacogenetics of Addiction Therapy

            David P. Graham, Mark J. Harding, and David A. Nielsen

 

17. Pharmacogenomics of Opioid Treatment for Pain Management

            Sarahbeth Howes, Alexandra R. Cloutet, Jaeyeon Kweon, Taylor L. Powell, Daniel Raza, Elyse M. Cornett, and Alan D. Kaye

 

18. The Role of Pharmacogenomics in Postoperative Pain Management

            E. Paylor Sachtleben, Kelsey Rooney, Hannah Haddad, Victoria L. Lassiegne, Megan Boudreaux, Elyse M. Cornett, and Alan D. Kaye

 

19. Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis

            Atinuke Aluko and Prabha Ranganathan

 

20. Pharmacogenomics in Children

            Michael J. Rieder and Abdelbaset A. Elzagallaai

 

21. Genetic Ancestry Inference for Pharmacogenomics

            I. King Jordan, Shivam Sharma, Shashwat Deepali Nagar, Augusto Valderrama-Aguirre, and Leonardo Mariño-Ramírez