Pharmaceutical Process Engineering and Scale-up Principles

ISBN-13: 9783031313790 / Angielski

Anil B. Jindal

Opis

The book offers a comprehensive overview of the unit operations involved in the manufacturing process of solid and liquid dosage forms, along with the scale-up of each operation. This book is a valuable resource for professionals working in the pharmaceutical industry and researchers seeking to develop a comprehensive understanding of the various aspects of the manufacturing process.The book is divided into four sections, covering a range of topics. Section I provide readers with a comprehensive understanding of the basic principles behind the manufacturing process of solid and liquid dosage forms.Section II covers the different unit operations involved in the production of solid dosage forms, including mixing, granulation, drying, compression, coating, and size reduction. This section includes case studies to provide readers with practical insights into the scale-up principles involved in the manufacturing process.Section III focuses on the manufacturing and scale-up of liquid formulations, covering topics such as mixing, filtration, and scale-up of liquid mixing process. This section offers a comprehensive understanding of the various aspects of the manufacturing process, including the challenges and opportunities associated with the scale-up of liquid formulations.Finally, Section IV includes two chapters that describe the manufacturing and scale-up of advanced drug delivery systems, including the manufacturing and scale-up of nanoparticles and biotechnology-derived products. This section provides readers with insights into the development of innovative drug delivery systems and the challenges involved in their scale-up.Overall, the book is an essential guide for professionals and researchers seeking a deeper understanding of the manufacturing process. The case studies and practical examples offer valuable insights into the challenges and opportunities involved in the scale-up process, making it an indispensable resource for those involved in the pharmaceutical industry.

•  Only book that is dedicated to pharmaceutical process engineering and scale-up;
•  Contain numerous case studies for easy reference;
•  Covers solid, liquid, and advanced dosage forms.

Spis treści

Part I: Physical properties of solids.- Part II: Mixing.- Rapid Mixer Granulator.- Fluid bed processing technology.- Drying.- Compression.- Pan coating.- Size reduction.- Part III: Mixing and filtration.- Scale-up of liquid mixing process.- Manufacturing process of nanoparticles.- Scale-up of nanoparticle manufacturing process.- Part 4: Manufacturing and scale-up of biotechnology-derived products.             

O autorze

Anil Jindal is an accomplished educator and drug delivery technologist. He has completed his PhD in Pharmaceutics at the Institute of Chemical Technology, Mumbai, India. After completing his studies, he worked as a Research Scientist at IPCA Laboratories, Mumbai. In 2014, he transitioned to academia and joined the Department of Pharmacy at Birla Institute of Technology and Science Pilani as an Assistant Professor and was promoted to Associate Professor in 2021. His research focuses on developing nanotechnology-based drug delivery systems to effectively deliver small molecules and therapeutic peptides. He has published numerous research papers and book chapters. He has received numerous awards for his work, including the Professor M. L. Khurana Memorial Award for the best research paper in Pharmaceutics and Biopharmaceutics in 2010, the Eudragit Award in 2017, and the Early Career Research Award in 2019. His supervised research has also been recognized with several awards, and one of his PhD students received the prestigious Sun Pharma Science Scholar Award in 2020. Considering his research contribution, he has been appointed as a managing theme editor of the Advanced Drug Delivery Reviews (Impact factor:17.87).