Pharmaceutical Powder ComPattion Technology

ISBN-13: 9780824793760 / Angielski / Twarda / 1995 / 634 str.

Goran Alderborn; Alderborn Alderborn;Nystrom Christer

Opis

This work examines modern pharmaceutical compacting techniques used to form tablets from powders. It describes the physical structure of pharmaceutical compacts, the bonding phenomena that occur during powder compaction, and the compression mechanisms of pharmaceutical particles. Fundamental theories of compaction are covered; questions of dominating bond types are investigated; and the bonding area between particles in pharmaceutical compacts is analyzed.

Spis treści

Interparticulate Bonding Characteristics of Pharmaceutical Compacts

Interparticulate Attraction Mechanisms, Claus Führer
The Importance of Intermolecular Bonding Forces and the Concept of Bonding Surface Area, Christer Nyström and Per-Gunnar Karehill

Characterization of the Compression Process

Porosity-Pressure Functions, Petteri Paronen and Jukka Ilkka
Force-Displacement and Network Measurements, Gert Ragnarsson
Viscoelastic Models, Fritz Müller
Application of Percolation Theory and Fractal Geometry to Tablet Compaction, Hans Leuenberger, Ruth Leu, and Jean-Daniel Bonny

Characterization of Compact Properties

Mechanical Strength, Peter N. Davies and J. Michael Newton
Tablet Surface Area, N. Anthony Armstrong
Rationale for and the Measurement of Tableting Indices, Everett N. Hiestand

Material Properties of Importance for Powder Volume Reduction and Compact Strength

Particle Dimensions, Göran Alderborn
Mechanical Properties, Ray C. Rowe and Ron J. Roberts
Granule Properties, Göran Alderborn and Martin Wikberg
Modeling the Compression Behavior of Particle Assemblies from the Mechanical Properties of Individual Particles, Wendy C. Duncan-Hewitt

Compaction Properties of Excipients and Powder Mixtures

Materials for Direct Compaction, Gerald K. Bolhuis and Zak T. Chowhan
Compaction Properties of Binary Mixtures, John T. Fell
Lubricant Sensitivity, Gerad K. Bolhuis and Arne W. Hölzer
The Development and Optimization of Tablet Formulations Using Mathematical Methods, Fridrun Podczeck

O autorze

Göran Alderborn, Christer Nyström