Pharmaceutical Perspectives of Cancer Therapeutics

ISBN-13: 9781441901309 / Angielski / Twarda / 2009 / 694 str.

Ram I. Mahato; Yi Lu

Opis

The goal of our efforts in compiling Pharmaceutical Perspectives of Cancer Therapeutic is to produce a comprehensive yet easy-to-follow review of the principles and current approaches in this ever-growing field. With today s broad research perspective and technology expertise, the knowledge in the field of cancer research and drug development has become a challenge not only for students who are eager to learn, but also for seasoned professionals who are willing to update. The complexity of cancer demands a comprehensive and integrated understanding from both cancer biology and pharmaceuticaldosage forms and drug delivery in order to warrant a successful therapeutic regimen. However, no book to date combinestogether these two aspects, namely the cancer research and the drug design and delivery from an integrated perspective of cancer treatment. Hence, a book that merges the knowledge from these two aspects is greatly desired. For the purpose of bridging basic research and clinical application, pharmaceutical drug development processes and regulatory issues, drug design and delivery, laboratory and translational experimentation, marketing and postmarketing surveillance, we have invited international experts with a multi-disciplinary background, including scientists and clinicians from both academia and industries in theirrespective fields to contribute to this book. We intend to convey both an introductory understanding and the latest development in the field so that this book can be useful for both novice students and practicing scientists. With a comprehensive and integrated view of cancer therapeutics, we hope that this book will stimulate a deeper understanding and promote interaction in this integrated field for people with diverse expertise and backgrounds who are working on cancer therapeutics. We have organized this book to cover a wide variety of topics including strategies to suppress tumor angiogenesis and metastasis, overcome multi-drug resistance in cancer, target telomerase and apoptosis pathways;therapeutic approaches to employ monoclonal antibody and cancer vaccines;introduction of new concepts such as cancer stem cells and new technologies such as nanobiotechnology, RNA interference, microRNA, and cancer cell gene profiling. The use of synthetic carriers, such as lipids, polymers and peptides for delivery and targeting of small molecules, proteins and nucleic acids to cancer cells or specific organs in vivo, as well as targeted delivery of macromolecular drugs to cancer cells, are described in detail. In addition, the utilization of imaging in cancer therapeutics, development and utilization of HIF-1 knockout animal models in cancer study, as well as the principles of developing anticancer drugs and designing clinical trials, are also discussed. In summary, this book provides an in-depth review of various aspects of anticancer strategies and drug delivery approaches from different perspectives, including detailed discussion of several clinical trial cases. The book has a wider and more involved focus on cancer therapy with a good balance on diversity. It integrates cancer therapy approaches (both biological- and small compound molecule-based therapy) with drug delivery. By reading this book, not only bench scientists can have an insight for what physicians desire for their clinical use towards cancer treatment, but also physicians will better understand how the approach and drug are developed and therefore will apply the drug more efficiently and accurately in patients. Moreover, this book summarizes current progress and state-of-the-art of cancer therapeutics, while focusing on the novel ideas that are being explored to overcome the existing challenges. We hope that this book will be served as both a refresher and ready-reference, as well as an educational tool, to both new entrants and seasoned researchers."

Spis treści

1. Tumor microvasculature and microenvironment: Therapeutic targets for inhibition of angiogenesis and metastasis Chikezie Madu and Yi Lu* 2. Anticancer drug development AjitNarang* and Divyakant S. Desai 3. Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor Takahiro Seki, Jun Fang, and Hiroshi Maeda* 4. Multidrug-resistance in solid tumor and its reversal Ho Lun Wong*, Xiao Yu Wu, and Reina Bendayan 5. Targeting of apoptosis signaling pathways and their mediators for cancer therapy Arun K. Rishi*, Xinbo Zhang, and Anil Wali 6. Role of telomerase in cancer therapeutics Kyung H. Choi and Michel M. Ouellette* 7. Polymeric carriers for anticancer drug delivery Dongin Kim and You Han Bae* 8. Application of nanobiotechnology in cancer therapeutics Kewal K. Jain 9. Receptor-mediated delivery of proteins and peptides to tumors Christian Dohmen and Manfred Ogris* 10. Protein transduction domain-mediated delivery of anti-cancer proteins Hiroshi Harada* and Masahiro Hiraoka 11. Current therapeutic uses of monoclonal antibodies Michael Axelson and David Gerber* 12. Cancer vaccines ZsuzsannaTabi 13. RNA interference for cancer therapy Kun Cheng* and Bin Qin 14. MicroRNAs as therapeutic targets for cancer Guofeng Cheng, Michael Danquah, and Ram I Mahato* 15. Targeted therapies for malignant brain tumors Matthew A. Tyler, Adam Quasar Sugihara, Ilya V. Ulasov, and Maciej S. Lesniak* 16. The complexity of the HIF-1-dependent hypoxic response in breast cancer presents multiple avenues for therapeutic intervention Tiffany Seagroves 17. Cancer stem cells: potential mediators of therapeutic resistance and novel targets of anti-cancer treatments Hong Yan, Jichao Qin, and Dean G. Tang* 18. Image-guided photodynamic cancer therapy Zheng-Rong Lu* and AnaghaVaidya 19. Functional imaging of multidrug resistance and its applications Célia Gomes 20.Gene expression microarrays in cancer research Jian Yang and Weikuan Gu* 21.Clinical trials and translational applications in cancer therapy Dineo Khabele and Derrick Beech

O autorze

Yi Lu graduated with B.S. in Biochemistry from Fudan University in Shanghai, China in 1984, and Ph.D. in Biochemistry and Molecular Biology from University of Nebraska Medical Center, Omaha, NE, USA in 1992. He is currently an Associate Professor at the Departments of Pathology, Medicine, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. His research interests include tumor angiogenesis and metastasis, gene therapy for prostate cancer and breast cancer, targeted gene expression, and exploration of novel apoptosis-inducing genes. He has more than 50 publications and holds five patents.

Ram I Mahato is a full time Associate Professor in the Department of Pharmaceutical Sciences at the University of Health Science Center Memphis. He was a Research Assistant Professor at the University of Utah Salt Lake City, Senior Scientist at GeneMedicine, Inc., The Woodland, TX, and postdoctoral fellow at the University of Southern California in Los Angeles, Washington University in St Louis and Kyoto University, Japan. He received his B.S. in Pharmaceutics from China Pharmaceutical University in 1989 and PhD in Pharmaceutics and Drug Delivery from the University of Strathclyde in 1992. He is an author or co-author of 79 peer reviewed articles and book chapters. He has also edited/written three books and is a special features editor of Pharmaceutical Research and on the editorial board of the Journal of Drug Targeting, Expert Opinion on Drug Delivery, and Transplantation and Risk Management. His research includes delivery and targeting of small molecules, oligonucleotides, siRNA and genes.

Blurb

Pharmaceutical Perspectives of Cancer Therapeutics presents a comprehensive yet easy-to-follow review of the principles, current progress and state-of-the-art of cancer therapeutics. The complexity of cancer demands an integrated understanding from both cancer biology and pharmaceutical dosage forms and drug delivery in order to warrant a successful therapeutic regimen. This book combines and merges the knowledge from these two aspects. Internationally acclaimed experts with a multi-disciplinary background, including scientists and clinicians from both academia and industries have contributed to this book to bridge the following areas between basic research and clinical application, pharmaceutical drug development processes and regulatory issues, drug design and delivery, laboratory and translational experimentation, marketing and postmarketing surveillance.

Main features of the book:

• Anticancer drug development and regulatory processes.
• Strategies to suppress tumor angiogenesis and metastasis, overcome multi-drug resistance in cancer, target telomerase and apoptosis pathways.
• Therapeutic approaches to employ monoclonal antibody and cancer vaccines.
• Introduction of new concepts such as cancer stem cells and new technologies such as nanobiotechnology, RNA interference, microRNA, and cancer cell gene profiling.
• Use of lipids, polymers and peptides for drug delivery and targeting to cancer cells or specific organs.
• Utilization of bioimaging and HIF-1 knockout animal models in cancer study.
• Clinical trials designs and principles