Pharmaceutical Formulation Development of Peptides and Proteins

ISBN-13: 9781439853887 / Angielski / Twarda / 2012 / 392 str.

Lars Hovgaard; Sven Frokjaer; Marco Van De Weert

Opis

This text looks at advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential.

Spis treści

Peptide Synthesis. Protein Expression. Protein Purification. Characterization of Therapeutic Peptides and Proteins. Chemical Pathways of Peptide and Protein Degradation. Physical Instability of Peptides and Proteins. Peptide and Protein Derivatives. Peptides and Proteins as Parenteral Solutions. Peptides and Proteins as Parenteral Suspensions. Rational Design of Solid Protein Formulations. Peptide and Protein Drug Delivery Systems for Nonparenteral Routes of Administration. Immunogenicity of Therapeutic Proteins. Biosimulation of Peptides and Proteins. Registration of Peptides and Proteins. Index.