Pharmaceutical Biotechnology: Fundamentals and Applications, Third Edition

ISBN-13: 9781420044379 / Angielski / Miękka / 2007 / 512 str.

Daan Crommelin

Opis

The field of pharmaceutical biotechnology is evolving rapidly. A new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry, and gene therapy. This introductory text explains both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists and for those already in the pharmaceutical industry.

Spis treści

Molecular Biotechnology. Biophysical and Biochemical Analysis of Recombinant Protein Structure and Analysis of Proteins. Production and Downstream Processing of Biotech Products. Formulation of Biotech Products, Including Biopharmaceutical Considerations. Pharmacokinetics and Pharmacodynamics of Peptide and Protein Drugs. Immunogenicity. Genomics, Proteomics and Additional Biotechnology-related Techniques. Gene Therapy. Oligonucleotides and siRNA. Hematopoetic Growth Factors. Interferons and Interleukins. Insulins. Growth Hormones. Recombinant Thrombolytics and Coagulation Factors. General Considerations of Monoclonal Antibodies. Monoclonal Antibodies in Oncology. Monoclonal Antibodies in Transplantation. Monoclonal Antibodies in Anti-inflammatory Therapy. Recombinant Human Deoxyribonuclease. Follicle-stimulating Hormone. Vaccines. Dispensing Biotechnology Products. Economic Considerations in Medical Biotechnology. Regulatory Issues and Drug Product Approval for Biopharmaceuticals

O autorze

Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm