Pet in the Evaluation of Alzheimer's Disease and Related Disorders

ISBN-13: 9780387764191 / Angielski / Twarda / 2009 / 215 str.

Dan Silverman

Opis

Among all the clinical indications for which radiologists, nuclear medicine phy- cians, neurologists, neurosurgeons, psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders. This demand is driven by the sheer prevalence of those conditions, coupled with the fact that the differential diagnosis for causes of cognitive impairment is wide and often difficult to distinguish clinically. The conceptual framework by which evaluation and management of dementia is guided has evolved considerably during the last decade. Although we still are far from having ideal tests or dramatic cures for any of the established causes of dementia, our options have expanded with respect to both the diagnostic and the- peutic tools now available. In the first chapter of this book, the contribution and limitations of different elements of the clinical examination for diagnosis of cog- tive symptoms are described, and the roles of structural and functional neuroim- ing in the clinical workup are given context.

Spis treści

Imaging Applications in Current Clinical Practice.- Clinical Evaluation of Dementia and When to Perform PET.- Clinical Interpretation of Brain PET Scans: Performing Visual Assessments, Providing Quantifying Data, and Generating Integrated Reports.- FDG PET in the Evaluation of Mild Cognitive Impairment and Early Dementia.- PET and SPECT in the Evaluation of Patients with Central Motor Disorders.- Emerging Approaches Using PET.- Microstructural Imaging of Neurodegenerative Changes.- Amyloid Imaging with PET in Alzheimer’s Disease, Mild Cognitive Impairment, and Clinically Unimpaired Subjects.- Atlas.- Interpretive Practice Atlas.

Blurb

The high demand for brain PET scans in dementia and related disorders is driven by both the prevalence of these conditions and the difficulty of distinguishing the causes of cognitive impairment. The clinical utility of brain PET in such cases depends in part on how accurately and fully the information inherently represented in a scan is appreciated and relayed in the interpretation of the images. Since this can be challenging for even the most highly trained imaging specialists, PET in the Evaluation of Alzheimer's Disease and Related Disorders takes a ground-up look at PET as it relates to the evaluation of patients with cognitive impairment. Expert contributors weigh in on when and why to order brain PET scans, their clinical interpretation, FDG PET in the evaluation of mild cognitive impairment and early dementia, PET and SPECT for central motor disorders, microstructural imaging of neurodegenerative changes, and amyloid imaging. The book is illustrated throughout with color images and also includes an interpretive practice atlas for self-testing of skills.