Pertussis Infection and Vaccines: Advances in Microbiology, Infectious Diseases and Public Health Volume 12

ISBN-13: 9783030332488 / Angielski / Twarda / 2020 / 170 str.

Giorgio Fedele; Clara Maria Ausiello

Recenzje

“The audience would most appropriately include individuals interested in microbiology, immunology, vaccinology, infectious disease, or public health. Readers who would benefit most would be at the graduate or professional level. … it would be a good starting point for a wide variety of learners.” (Kari Neemann, Doody's Book Reviews, February 26, 2021)

Spis treści

1.  Evolution of the genus Bordetellae

Corresponding author:  Andrew Preston   Email : A.Preston@bath.ac.uk

2.  Molecular epidemiology of B. pertussis 

Corresponding author: Qiushui He    Email : qiuhe@utu.fi

 

3.  Role of major virulence factors in pertussis infection and disease pathogenesis

 Corresponding author: Nick Carbonetti    Email : ncarbonetti@som.umaryland.edu

4. Functional programming of innate immune cells in response to B. pertussis infection and vaccination

 Corresponding author: Dimitri Diavatopoulos    Email : Dimitri.Diavatopoulos@radboudumc.nl

5.  Superior imprinting of B. pertussis specific CD4+ T cell immunity by natural infection

Corresponding author: Cecile ACM van Els     Email : cecile.van.els@rivm.nl

6. Human immune responses to pertussis vaccines

Corresponding author: Giorgio Fedele     Email : giorgio.fedele@iss.it 

7.  Pertussis: diagnosis, prevention and control 

Corresponding author: Paola Stefanelli   Email : paola.stefanelli@iss.it

8.  Pertussis on low- and middle-income countries (LMIC): a pragmatic approach 

Corresponding author: Nicole Guiso    Email : nicole.guiso@pasteur.fr

9.  Clinical findings and management of pertussis 

Corresponding author: Susanna Esposito   Email : susanna.esposito@unipg.it

10.  Need for improved immunization strategies. 

Corresponding author: Antonio Cassone    Email : antonio.cassone2@gmail.com

11.  New pertussis vaccines: a need and a challenge. 

Corresponding author: Daniela Hozbor    Email : hozbor.daniela@gmail.com

O autorze

Dr. Giorgio Fedele

Istituto Superiore di Sanità

Roma, Italy

Email : giorgio.fedele@iss.it

 

Dr. Clara Maria Ausiello

Roma, Italy

Email : clara.ausiello@gmail.com

Blurb

This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines.

Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.

This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.