Personalized Epigenetics

ISBN-13: 9780124201354 / Angielski / Twarda / 2015 / 610 str.

Tollefsbol, Trygve

Opis

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

• Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures
• Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field
• Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development
• Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Spis treści

Section I: Overview

1. Epigenetics of Personalized Medicine

Section II: Epigenetic Variations Among Individuals

2. Inter-individual Variability of DNA Methylation

3. Differences in Histone Modifications Between Individuals

4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape

5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation

Section III: Bioinformatics of Personalized Epigenetics

6. Computational Methods in Epigenetics

Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine

7. Epigenetic Biomarkers in Personalized Medicine

8. Epigenetic 'Fingerprint'

9. Epigenetics of Personalized Toxicology

Section V: Environmental Personalized Epigenetics

10. Environmental Contaminants and their Impacts on the Epigenome

11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

Section VI. Pharmacology and Drug Development of Personalized Epigenetics

12. Personalized Pharmacoepigenomics

13. Personalized Medicine and Epigenetic Drug Development

Section VII: Personalized Epigenetics of Disorders and Disease Management

14. Epigenetics and Personalized Pain Management

15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management

16. Epigenetic Modification of miRNAs in Cancer

17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches

18. Cardiovascular Diseases and Personalized Epigenetics

Section VIII: Challenges and Future Directions

19. Future Challenges and Prospects for Personalized Epigenetics

O autorze

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O'Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.