Peripheral Nerve Tissue Engineering and Regeneration

ISBN-13: 9783030210519 / Angielski / Twarda / 2022 / 400 str.

James Phillips; David Hercher; Thomas Hausner

Spis treści

The History of Nerve Repair.- Part I: The Peripheral Nerve Repair Environment. - Blood Supply and Microcirculation of the Peripheral Nerve.- The Immune Response and Implications for Nerve Repair.- Autonomic Nervous System Repair and Regeneration.- Part II: Models and Evaluation of Peripheral Nerve Regeneration.- Appropriate Animal Models for Translational Nerve Research.- Basic Nerve Histology and Histological Analyses Following Peripheral Nerve Repair and Regeneration.- Mathematical Modelling for Nerve Repair Research.- Part III: Biomaterials for Peripheral Nerve Regeneration.- Biomaterials and Scaffolds for Repair of the Peripheral Nervous System.- Fibrin in Nerve Tissue Engineering.- Silk Biomaterials in Peripheral Nerve Tissue Engineering.- Collagen Biomaterials for Nerve Tissue Engineering.- Part IV: Therapeutic Options for Peripheral Nerve Regeneration.- Schwann Cells in Nerve Repair and Regeneration.- Therapeutic Cells and Stem Cells for Nerve Regeneration.- Extracellular Vesicles for Nerve Regeneration.- Drug Therapies for Peripheral Nerve Injuries.- Part V: Clinical Aspects. -Surgical Techniques in Nerve Repair.- Clinical Outcome Measures Following Peripheral Nerve Repair.- Regenerative Therapies for Acquired Axonal Neuropathies.- Rehabilitation of Nerve Injuries.

O autorze

James B. Phillips is Professor of Regenerative Medicine and Vice Dean (Innovation and Enterprise) in the Faculty of Life Sciences at University College London. He is also co-Director of the UCL Centre for Nerve Engineering and Chief Scientific Officer of the UCL spinout company Glialign Ltd. His research focus on translational neuroscience includes construction of living artificial tissues for regenerative medicine; developing novel cell, drug, gene, and biomaterial therapies for neural repair and protection; and advanced 3D co-culture models. Applications include treating and modeling neurodegenerative diseases and traumatic injury to peripheral nerves, the spinal cord, and the brain. His multi-disciplinary research group is based in the Department of Pharmacology at the UCL School of Pharmacy, and uses in silico, in vitro, in vivo, and clinical approaches. Professor Phillips has been involved in nerve tissue engineering and regeneration research for more than 20 years. His lab pioneered Engineered Neural Tissue (EngNT) and is developing other biomaterial and small molecule therapeutics to treat nerve injury, as well as investigating the cellular, molecular, and mechanical properties of nerves.

David Hercher obtained his MSc in molecular biology from the University of Vienna and his Dr. scient. med. from the Medical University of Vienna. Since 2017, he is the head of the Neuroregeneration Group at the Ludwig Boltzmann Institute for Traumatology, where he has worked for 12 years in the field of regenerative medicine. His group focuses its research on the investigation of regenerative processes after injuries to the nervous system and the subsequent development of novel treatment options for peripheral and central nervous injuries. Furthermore, the group’s interests lie in the elucidation of modes of action of mechanical stimuli on neuronal/glial cells and tissues as well as non-viral gene therapy and novel imaging modalities and their application in the field of regenerative medicine.

Thomas Hausner was born in Salzburg, Austria, in 1965. He is Doctor of Medicine since 1993. His specializations in Medicine are General and Visceral Surgery, Trauma Surgery, and Hand- and Microsurgery. Currently he is Head of AUVA Trauma Center Vienna, Lorenz Böhler, Austria, and Co-Director of Ludwig Boltzmann Institute for Traumatology, located at Trauma Center Lorenz Böhler. Postdoctoral Lecture Qualification for Trauma Surgery at Paracelsus Medical University Salzburg in 2015. His main field of research is regeneration of peripheral nerves after trauma. This includes effects of extracorporeal shock wave therapy on nerve regeneration, bridging nerve defects and neural plasticity after injury to the peripheral nerval system.Especially bridging nerve defects is a tissue engineering topic, e.g., the development of nerve scaffolds and tubes from silk or different other materials. Furthermore, together with his fellows he is working on various aspects of hand trauma like scaphoid fractures and their delayed healing as well as distal radius fractures. A new field for the research group is the use artificial intelligence through deep learning systems in radiodiagnostic of fractures. Dr. Hausner is also member of the German Nerve Club, an interdisciplinary nerve study group.