Perioperative Inflammation as Triggering Origin of Metastasis Development

ISBN-13: 9783319579429 / Angielski / Twarda / 2017 / 236 str.

Michael Retsky; Romano Demicheli

Opis

The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome.

Spis treści

Chapter 1. The Natural History of Breast Cancer

Chapter 2. Perioperative Inflammation as Triggering Origin of Metastasis Development 

Chapter 3. Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients

Chapter 4. Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation

Chapter 5. Circulating tumor cells as predictive marker in metastatic disease

Chapter 6. Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints

Chapter 7. Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs 

Chapter 8. The impact of wound inflammation on cancer progression; Studies in fish and patients

Chapter 9. Long term consequences of acute inflammation in cancer surgery: New findings and perspectives

Chapter 10. Cancer: Nurture and Nature

Chapter 11. The systemic effects of local treatments (surgery and radiotherapy) of breast cancer

O autorze

Michael Retsky, PhD, is Research Associate, Harvard TH Chan School of Public Health and Honorary Faculty, University College London

Romano Demicheli, MD, PhD, is Senior Researcher, Istituto Nazionale Tumori di Milano

Blurb

The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.

With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.