Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods

ISBN-13: 9781138351233 / Angielski / Twarda / 2021 / 990 str.

Nina Dragicevic; Howard Maibach

Opis

Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption supplies new studies on the role of the skin as a key portal of entry for chemicals into the body this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel.

Spis treści

1 Molecular structure and function of the skin barrier  2 Mathematical Models in Percutaneous Absorption   3 In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/ Vehicle Partitioning   4 The Skin Reservoir for Topically Applied Solutes   5 Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying Interaction of Chemicals and Human Skin  6  Variations of Hair Follicle Size and Distribution in Different Body Sites   7 In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss     8 The correlation between transepidermal water loss and percutaneous absorption: An updated overview   9 Human Percutaneous Absorption and Transepidermal Water Loss (TEWL) Correlation     10 Evaluation of Stratum Corneum Heterogeneity   11 Regional Variation in Percutaneous Absorption: Principles and Applications to Human Risk Assessment   12 Effects of Anatomical Location on In Vivo Percutaneous Penetration in Man    13 Interrelationships in the Dose-Response of Percutaneous Absorption   14 Effects of Occlusion: Percutaneous Absorption     15 Occlusion Does Not Uniformly Enhance Penetration In Vivo  16 Effect of Single vs. Multiple Dosing in Percutaneous Absorption   17 Influence of formulation on topical and transdermal drug delivery  18 In Vitro Release from Semisolid Dosage Forms—What Is Its Value?  19 Understanding Skin Metabolism: Effect on Altering In Vitro Skin Absorption and Bioavailability of Topically Applied Chemicals  20 Phenomenon of Lateral Spread in Percutaneous Penetration   21 Clinically Pertinent Factors/Observations Affecting Percutaneous Absorption in Humans    22 Percutaneous Absorption of Chemical Mixtures   23 Dermal Decontamination and Percutaneous Absorption   24 Skin Decontaminartion  25 Chemical Warfare Agent VX Penetration Through Military Uniform and Human Skin: Risk Assessment and Decontamination  26 Percutaneous Absorption of Hazardous Chemicals from Fabric into and Through Human Skin  27 Percutaneous Absorption of Chemicals from Fabric (Textile)  28 The Fate of Material Remaining in Skin in In Vitro Absorption Studies    29 Skin Absorption of Hair Dyes  30 Hair Dye Penetration in Monkey and Man  31 Percutaneous Absorption of Sunscreens  32 Sunscreen Percutaneous Penetration in Vivo in Man   33 Cutaneous Metabolism of Xenobiotics  34 Chemical modification: an important and feasible method for improving peptide and protein dermal and transdermal delivery   35 Enchancing Percutaneous Penetration of Oligonucleotide Drugs   36 Use of Microemulsions for Topical Drug Delivery  37 Transdermal Delivery of Vesicular Nanocarriers Under Electrical Potential  38 Nanocarriers and physical methods   39 Assessment of Microneedles for Transdermal Drug Delivery  40 Clinical Testing of Microneedles for Transdermal Drug Delivery  41 Delivery of drugs, vaccines, and cosmeceuticals to skin using microneedle patches   42 Mirconeedle dermatotoxicology  43 Transdermal Transport by sonophoresis   44 Effect of Tape Stripping on Percutaneous Penetration and Topical Vaccination  45 Transcutaneous Delivery of Drugs by Electroporation   46 IONTOPHORESIS IN PENETRATION ENHANCEMENT  47 VEHICLES AND TOPICAL THERAPY  48 The role of in vitro skin models in optimization of dermal drug delivery   49 Effects of phospholipids on skin: use of primary human keratinocytes and fibroblasts as 2D cell culture models   50 Human cadaver skin viability for in vitro percutaneous absorption: storage and detrimental effects   51 Determination of Percutaneous Absorption by In Vitro Techniques  52 Stripping Method for Measuring Percutaneous Absorption In Vivo  53 Tape Stripping - Technique and Applications  54 Blood flow as technology in percutaneous absorption  55 Confocal Raman Microspectroscopy in the assessment of skin barrier function and drug penetration  56 Microscopy methods for assessing percutaneous drug penetration  57 Dermal sampling techniques with focus on dermal Open Flow Microperfusion   58 Dermal-epidermal Separation Methods: Research Implications  59 Use of Skin Absorption Data in the Safety Evaluation of Cosmetic Ingredients  60 BIOEQUIVALENCE, PHARMACEUTICAL EQUIVALENCE AND BIOWAIVERS – TOPICAL DOSAGE FORMS FOR LOCAL ACTION  61 In Vitro Human Nail Model To Evaluate Ungual Absorption and Transungual Delivery  62 Drug Permeation through Burn Eschar: Possibilities and Improvements