Peptide and Protein Drug Delivery

ISBN-13: 9780824778965 / Angielski / Twarda / 1990 / 912 str.

Vincent H. L. Lee; Lee Lee; Vincent Lee

Opis

Covers fundamentals of peptide and protein drug delivery. This reference/text includes such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics as well as bioavailability from routes of administration.

Recenzje

". . .extremely well written in terms of both clarity and organization of the material. . .. If you or your library does not already have a copy of this book, buy it immediately."
---Journal of Controlled Release
". . .provides exceptional detail."
---American Journal of Pharmaceutical Education
"An outstanding contribution to the field."
---Biomaterials

Spis treści

"Fundamentals Changing Needs in Drug Delivery in the Era of Peptide and Protein Drugs Synthesis of Peptides and Proteins by Chemical and Biotechnological Means Physical Biochemistry of Peptide Drugs: Structure, Properties, and Stabilities of Peptides Compared with Proteins Physical Biochemistry of Protein Drugs Analysis of Peptide Drugs Analysis of Protein Drugs Enzymatic Barriers Intestinal Epithelial and Vascular Endothelial Barriers to Peptide and Protein Delivery Pharmacokinetics and Pharmacodynamics of Peptides Routes of Delivery Parenteral Routes of Peptide and Protein Drug Delivery Nasal Route of Peptide and Protein Drug Delivery Buccal Routes of Peptide and Protein Drug Delivery Oral Route of Peptide and Protein Drug Delivery Rectal Route of Peptide and Protein Drug Delivery Vaginal Route of Peptide and Protein Drug Delivery Transdermal Route of Peptide and Protein Drug Delivery Practical Considerations Preformulation and Formulation Considerations of Peptide Drugs: Case History of an LHRH Analog Mucosal Dosage Forms for Peptide and Protein Delivery Controlled Delivery Systems for Peptides Characterization of the Toxicity Profile of Peptide and Protein Therapeutics Reduction of Immunogenicity and Extension of Circulating Half-Life of Peptides and Proteins Regulatory Perspective of Peptide and Protein Drug Development "

O autorze

Vincent Lee