Peptide-Based Cancer Vaccines

ISBN-13: 9781587060267 / Angielski / Twarda / 2000 / 231 str.

W. Martin Kast

Opis

The field of peptide based cancer vaccines has evolved tremendously in the last decade of this century. The exploration on how to apply the peptide knowledge for vaccination purposes began when it was demonstrated that these peptides after being mixed into adjuvants actually induced T cell responses that could prevent virus infections and tumor growth in experimental animal models. The results of animal models are currently translated into clinical applications with all their associated difficulties and heterogeneity. Initial promising data do appear, warranting further research in this area. This book pays tribute to key researchers in the field.

Spis treści

1. Identification and Selection of T-Cell Epitopes Derived from Tumor-Associated Antigens for the Development of Immunotherapy for Cancer 2. Mutant Oncogene and Tumor Suppressor Gene Products and Fusion Proteins Created by Chromosomal Translocations as Targets for Cancer Vaccines 3. p53: A Target for T-Cell Mediated Immunotherapy 4. Critical Dependence of the Peptide Delivery Method on the Efficacy of Epitope Focused Immunotherapy 5. Cancer Peptide Vaccines in Clinical Trials 6. Carcinoembryonic Antigen (CEA) Peptides and Vaccines for Carcinoma 7. Studies of M UCl Peptides 8. Cytotoxic T Cell Epitopes and Tissue Distribution of the HER-2/neu Proto-Oncogene: Implications for Vaccine Development 9. Clinical Trials of HER-2/neu Peptide-Based Vaccines 10. Peptides in Prostate Cancer 11. Peptides in Cervical Cancer 12. Peptide Vaccines for the Treatment of Melanoma 13. GplOO and G250: Towards Specific Immunotherapy Employing Dendritic Cells in Melanoma and Renal Cell Carcinoma 14. Melanoma Peptide Clinical Trial

O autorze

Kast, W. Martin