Pediatric Nephrology

ISBN-13: 9783030527181 / Angielski / Twarda / 2022 / 2500 str.

Francesco Emma; Stuart L. Goldstein; Arvind Bagga

Spis treści

I Developmental Physiology and Diseases

1. Pre-natal development of the kidneys and urinary tract

2. Post-natal renal maturation

3. Congenital abnormalities of the kidneys and the urinary tract

4. Stem cells and kidney regeneration 

II Renal Physiology and Diagnostic Approaches

5. Assessment of kidney function

6. Imaging kidneys and the urinary tract  

7. Technical aspects of renal pathology

8. Approach to the child with hematuria and/or proteinuria

III Glomerular Diseases

9. Nephrotic syndrome: classification and evaluation

10. Genetic bases of nephrotic syndrome

11. Congenital nephrotic syndrome

12. Clinical aspects of genetic forms of nephrotic syndrome

13. Inherited diseases of the glomerular basement membrane

14. Steroid sensitive nephrotic syndrome

15. Non-genetic forms of steroid resistant nephrotic syndrome

16. Membranous nephropathy 

IV Kidney Involvement in Systemic Diseases

17. Evaluation of children with nephritic syndrome

18. IgA Nephropathy

19. Henoch Schönlein Purpura Nephritis

20. Renal vasculitis 

21. Lupus nephritis

22. Autoantibodies and kidney diseases

23. C3 glomerulopathies

24. Atypical HUS and TTP

25. Infection-related HUS

26. Acute post-streptococcus glomerulonephritis

27. Infections that affect the kidney (non-viral)

28. Viral infections and the kidney

29. The kidney in sickle cell disease

30. The kidney in type I diabetes

31. The kidney in metabolic syndrome

32. Renal Manifestations of Metabolic Disorders

33. The kidney in methyl malonic acidemia

34. The kidney in mitochondrial cytopathies

35. Fabry disease

36. Primary hyperoxaluria 

V Renal Tubular Disorders

37. Fanconi Syndrome

38. Cystinosis

39. Aminoaciduria and Glycosuria

40. Renal hypophosphatemia

41. Inherited disorders of sodium and potassium handling

42. Inherited disorders of renal magnesium handling 

43. Inherited disorders of renal calcium handling 

44. Renal Tubular Acidosis

45. Inherited disorders of water handling

46. Tubulointerstitial nephritis

VI Homeostasis

47. Sodium and Water Disorders: evaluation and management

48. Potassium disorders: evaluation and management

49. Clinical use of diuretics 

VII Cystic Kidney Diseases and Related Disorders

50. Autosomal Dominant Polycystic Kidney Diseases

51. Autosomal Recessive Polycystic Kidney Diseases

52. Renal involvement in tuberous sclerosis

53. Nephronophtisis and other ciliopathies

54. Autosomal Dominant Tubulointerstitial Kidney Diseases 

VIII Urinary Tract Disorders

55. Urolithiasis and nephrocalcinosis

56. Urinary tract infections

57. Vesicoureteral reflux

58. Obstructive uropathies

59. Bladder disorders

60. Enuresis

61. Pediatric renal tumors

62. Onconephrology 

IX Hypertension

63. Pathophysiology and epidemiology of hypertension in children

64. Evaluation and management of hypertension

65. Renovascular hypertension: evaluation and management 

X Acute Kidney Injury

66. Pathogenesis of acute kidney injury

67. Evaluation and management of acute kidney injury in neonates

68. Evaluation and management of acute kidney injury in children

69. Nephrotoxins

XI Chronic Kidney Failure

70. Progression of chronic kidney disease and nephroprotection

71. Epidemiology and management of Chronic Kidney Disease

72. Nutrition, Growth and Development

73. CKD-MBD

74. Anemia in CKD

75. Assessment of volume status in CKD

76. Peritoneal Dialysis

77. Hemodialysis

78. Infant dialysis

79. Adequacy of dialysis

80. Renal Transplantation: Evaluation of children and donors

81. Renal transplantation: surgical and perioperative management

82. Renal transplantation: immunosuppression

83. Renal transplantation: disease recurrence

84. Renal transplantation: infectious complications

85. Renal transplantation: non- infectious complications and long-term outcome

86. Multi-organ transplants and the kidney in other solid organ transplantation

87. Ethical issues in pediatric nephrology

88. Drug dosing in abnormal kidney functions in Children with Abnormal Renal Function

XII Addendum

89. Normal reference values

O autorze

Francesco Emma, MD

Bambino Gesù Children’s Hospital – IRCCS

Division of Nephrology

Rome, Italy

Stuart L. Goldstein, MD

Director, Center for Acute Care Nephrology 

Medical Director, Pheresis Service

Co-Director, Heart Institute Research Core

Cincinnati Children's Hospital Medical Center

Division of Nephrology and Hypertension

Cincinnati, OH

USA

Arvind Bagga, MD

All India Institute of Medical Sciences

Division of Nephrology

Ansari Nagar, New Delhi

India

Carlton M. Bates, MD

Chief, Division of Pediatric Nephrology

Children’s Hospital of Pittsburgh 

University of Pittsburgh Medical Centerr

Pittsburgh, PA

USA

Rukshana Shroff, MD, FRCPCH, PhD

Great Ormond Street Hospital for Children

NHS Foundation Trust

London, UK

Dr. Emma received his Medical Degree and specialized in Pediatrics from the Catholic University of Louvain, Brussels, Belgium. He then completed his training in Pediatric Nephrology at Boston Children's Hospital, Harvard Medical School. In 1998, Dr. Emma moved to the Bambino Gesù Children's Hospital - IRCCS, in Rome, where he has set-up the Nephrology Research Laboratory and was appointed Chief of the Division of Pediatric Nephrology in 2005. He currently holds the position of Head of the Department of Pediatric Subspecialties.

Dr. Emma has authored more than 160 research articles in peer-reviewed journals and is the author of several textbook chapters and one of the editors of the Pediatric Nephrology textbook. He is the chair of the ESPN (European Society of Pediatric Nephrology) Working Group on Inherited Renal Disorders. His primary research interests are in rare renal diseases, in particular cystinosis and idiopathic nephrotic syndrome.

Stuart L. Goldstein, MD, has been an active investigator in the field of pediatric acute kidney injury (AKI) since 2000. Dr. Goldstein’s main research foci include: AKI epidemiology and outcomes, acute renal replacement therapy provision and investigation of novel urinary AKI biomarkers in the pediatric population. Dr. Goldstein has established a strong record of interdisciplinary and inter-institutional collaboration with cardiologists, intensivists and emergency center physicians, which is evidenced by his establishment and directing of the Prospective Pediatric Continuous Renal Replacement Therapy Registry from 2001 to 2012, and the Prospective Pediatric AKI Research Group (ppAKI-RG) in 2012. The ppAKI-RG is comprised of 52 centers from around the world with the goal of improving outcomes for the child with or at-risk for, AKI.

Carl Bates, MD, has had a career as a clinical pediatric nephrologist and basic research scientist for over 15 years. Dr. Bates was recruited to Children’s Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine in 2008, where he is currently Professor of Pediatrics, Cell Biology and Developmental Biology; Vice Chair of Basic Research in Pediatrics, Division Chief of Pediatric Nephrology; and co-Director of the Pediatric Nephrology Fellowship Training Program.

In addition to caring for children with pediatric kidney disease for many years, Dr. Bates has had an internationally-recognized research program focused on genetic regulation of kidney and bladder development, with more than 15 years of continuous funding by the National Institutes of Health. His mouse models of kidney and bladder disease have helped us understand many of the structural kidney and bladder birth defects seen in children, which make up the most frequent causes of kidney disease in children.

Dr. Shroff is a Consultant Pediatric Nephrologist at Great Ormond Street Hospital and looks after children with chronic kidney disease (CKD) and those on dialysis.

Dr. Shroff’s PhD and current research focus on cardiovascular disease in children with CKD, with particular emphasis on identifying and reducing the burden of modifiable risk factors in dialysis patients. She has supervised 3 MSc students and currently co-supervises 2 PhD students.

She says "I hope that my approach through ‘translational’ (bench-to-bedside) research will improve the lives of dialysis patients by reducing their risks of heart disease and bone problems".

She has published widely in her field and written educational reviews and book chapters.

Dr. Shroff is an associate editor for Pediatric Nephrology, the main journal in the field.