Patient-Derived Xenograft Models of Human Cancer

ISBN-13: 9783319857589 / Angielski / Miękka / 2018 / 204 str.

Opis

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

Spis treści

Section I: Introduction

History and Evolution of PDX Cancer Models

Section II: Establishment and Characterization of PDX Models

Methods of Generating PDX Models

Fidelity and Stability of PDX Models

Section III: Applications of PDX Models

Studies of Cancer Heterogeneity

PDX and Cancer Stem Cells

Modeling Cancer Metastasis

Modeling Drug Resistance

PDX and Biomarker Development

PDX and Preclinical Drug Screening

Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine

Section IV: Epilogue

Future Perspective.

O autorze

Yuzhuo Wang, PhD

Director, Living Tumor Laboratory

Distinguished Scientist, BC Cancer Agency

Senior Scientist, Vancouver Prostate Centre

Professor, University of British Columbia

675 West 10th Avenue, Room 3.122

Vancouver, BC, Canada V5Z 1L3

Dong Lin, PhD, MD

Research Pathologist, Living Tumor Laboratory

Peter W. Gout, PhD

Scientific Consultant, Living Tumor Laboratory

Honorary Associate Professor, Department of Urologic Sciences, University of British Columbia

Emeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer Agency

<675 West 10th Avenue, Room 5.108

Vancouver, BC, Canada V5Z 1L3