Pathophysiology of Obesity-Induced Health Complications

ISBN-13: 9783030353575 / Angielski / Twarda / 2020 / 345 str.

Paramjit S. Tappia; Bram Ramjiawan; Naranjan S. Dhalla

Spis treści

A. INTRODUCTION

Title: Pathophysiology of obesity-induced health complications

 

B. DIABETES/METABOLIC DISEASE

1. The effects of biological sex on adipose tissue biology and energy metabolism

2. Effect of maternal obesity on birthweight and neonatal fat mass

3. Association of maternal hyperglycemia exposure during pregnancy with obesity and abnormal glucose tolerance in offspring

4. Lifestyle interventions for the management of obesity

5. Obesity phenotypes: depot-differences in adipose tissue and their clinical implications

6. Autophagy Dysregulation and Obesity-Associated Pathologies

 

C. ISCHEMIC HEART DISEASE

1. Obesity and coronary artery disease: evaluation and treatment

2. Premature Coronary Heart Disease in South Asians: Burden and Determinants

3. Coronary artery disease in patients with body mass index ≥30 kg/m2

4. “Obesity paradox” in coronary artery disease

5. Association of body mass index with mortality and cardiovascular events for patients with coronary artery disease

6. Relationship between adipose tissue and onset and progression of atherosclerosis

7. Title LOX-1 in atherosclerosis and obesity

8. The influence of NAFLD on the risk of atherosclerosis in obesity

9. Relationship between atrial fibrillation, atherosclerosis and obesity

10. Role of epicardial adipose tissue in coronary artery disease

 

D. MENTAL ILLNESS/SLEEP DISORDERS

1. Relationship between obesity and brain illness

2. Obesity and vulnerability of the CNS

3. Impairment of cognitive and motor function in obesity

4. The psychosocial impact of pediatric obesity

5. Sleep problems in adolescence and overweight/obesity in young adults: is there a causal link?

6. Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms

7. Role of sex and the environment in moderating weight gain due to inadequate sleep

 

E. CANCER

1. Inflammatory mechanisms of obesity-induced cancer

2. Obesity and cancer: existing and new hypothesis for a causal connection

3. Obesity and cancer: evidence, impact and future directions

4. Metabolic perturbations and the obesity-cancer link

5. Insights into the relationship between cancer and obesity

F. FERTILITY

1. Obesity as disruptor of the female fertility

2. Mechanisms of male infertility in obesity

3. The impact of obesity on reproduction systems

4. Obesity and female infertility: potential mediators of obesity’s impact

5. Obesity, male infertility, and the sperm epigenome

 

G. MUSCULOSKELETAL DISORDERS

1. Biomechanics, obesity and osteoarthritis: the role of adipokines

2. Inflammatory pathways in loss of muscle integrity in obesity

3. Adipokine contribution to the pathogenesis of osteoarthritis

4. Obesity and osteoarthritis

5. Leptin in osteoarthritis

6. Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis in obesity

 

H. LIVER AND KIDNEY DISEASE

1. Altered kidney function in obesity

2. The renal pathology of obesity

3. Obesity and its relationship with chronic kidney disease

4. Mechanisms of kidney disease in obesity

5. The role of the liver in obesity

6. Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease

7. The Pathophysiology of Non-alcoholic Fatty Liver Disease in obesity

8. Lipid droplets and liver disease in obesity

9. Gastrointestinal morbidity: impact on organ function in obesity

Blurb

According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a  number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. 

The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. 

Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.