Pathology of Graft vs. Host Disease: A Case Based Teaching Guide

ISBN-13: 9783319420981 / Angielski / Twarda / 2019 / 251 str.

Cecilia Yeung; Howard Shulman

Opis

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, pathologists and researchers with an interest in GVHD and its mimickers. The book reviews new data about risk factors for the disease, pathologic features, profiles the new WHO guidelines as well as current practices. It also provides examples of various presentations of GVHD in Skin, GI system, and Liver in addition to major teaching points through patient based teaching cases. Comparative gross and histologic pictures of GVHD are provided. Another unique aspect to this text is the implementation of patient cases as the focus for the major chapters to be the discussion initiation points, making the reading and teaching more interactive with the readers and at the same time providing a stimulating discussion of difficult differentials. Bonus cases are also added to showcase important differentials with similar morphologies. Pathology of Graft vs. Host Defense will serve as a very useful image heavy, case based resource for physicians and researchers dealing with, and interested in, this challenging disease. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters arebe written by experts in their fields and include the most up to date scientific and clinical information.

Spis treści

The Contributions of Pathology to the Diagnosis and Management of GVHD - Caveats and Lessons Learned.- Evolutions in the Clinical Management of GVHD.- Early GVHD with Follicular Rash.- The Basic Sequence of Injury in Acute Skin GVHD.- Leukemia Cutis and Hematologic Malignancies with Cutaneous Manifestation.- Lichenoid Inflammatory Phase of Chronic Skin GVHD.- Cutaneous Chronic GVHD: Sclerodermatous and Morpheic Variants.- Early Changes of Gut GVHD; Criteria for Crypt Cell Apoptosis and the Differential Diagnosis.- Persistent Gastrointestinal GVHD: The Application and Utility of Histologic Grading Schemes.- Chronic, Persistent, and Fatal Gastrointestinal GVHD.- Abdominal Pain and Diarrhea When it is Not GVHD.- Mucosal Chronic GVHD Affecting the Oral Pharyngeal, Esophageal, and Anogenital Regions.- Pre-Transplant Liver Disorders: Post-Transplant Impact on Developing Venocclusive Disease/Sinusoidal Occlusive Disease and Other Hepatic Problems.- The Pathological Spectrum of Hepatic GVHD.- Rapidly Progressing Cholestatic Liver Failure after Allogeneic Stem Cell Transplant from Hepatitis C Positive Donor (FCHCV).- Acute Hepatitic Onset of Liver GVHD Occurring 9 Months Post-Transplant.- GVHD Manifesting as Sicca Syndrome.- Non-Infectious Pulmonary Manifestation of GVHD: Bronchiolitis Obliterans Syndrome.- Kidney Involvement in GVHD.- Manifestations of Chronic GVHD in Other Organ Systems.

O autorze

Cecilia CS Yeung

Fred Hutchinson Cancer Research Center

University of Washington

Seattle, WA

USA

Howard M. Shulman

Seattle Cancer Care Alliance

Seattle, WA

USA

Blurb

GVHD is the major cause of non-relapse morbidity and mortality after hemopoietic cell transplantation. This text provides a comprehensive, state-of-the art review of the pathology of GVHD for clinicians, pathologists and researchers with an interest in GVHD. The book covers the histologic spectrum of GVHD, clinicopathologic features, pathobiology, grading, risk factors affecting outcome, and differential diagnosis. It profiles the new NIH consensus and international guidelines for diagnosing GVHD. The text chapters are based on actual patient cases covering the gamut of acute and chronic GVHD and associated complications.  The discussion initiated teaching points and key histologic points make the reading and teaching more interactive while providing a stimulating discussion of difficult differentials. The chapters are richly illustrated with colored comparative gross and histologic images and include extensive references by experts in the fields including the most up-to-date scientific and clinical information. 

 

Pathology of Graft vs. Host Defense: A Case Based Teaching Guide serves as a useful resource for physicians and researchers interested in this challenging disease. It also provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts.