Pathology of Genetically Engineered and Other Mutant Mice

ISBN-13: 9781119624578 / Angielski / Twarda / 2022 / 560 str.

John P. Sundberg; Jerrold M. Ward; Peter Vogel

Spis treści

List of Contributors viiPreface and Acknowledgments x1 Introduction to Mouse Pathology 1Jerrold M. Ward, Peter Vogel, and John P. Sundberg2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research 6Dale A. Begley, Paul N. Schofield, and John P. Sundberg3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics 22John P. Sundberg, Dale A. Begley, Melissa L. Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect 39John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofield5 Embryos, Placentas, and Neonates 48Brad Bolon and Jerrold M. Ward6 Ciliopathies 72Peter Vogel and Laura J. Janke7 Hematopoietic and Lymphoid Tissues 82Harm HogenEsch and John P. Sundberg8 Mouse Hematolymphoid Neoplasms 97Jerold E. Rehg9 Immunodeficient and Humanized Mice 132Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch10 Skin, Hair, and Nails 159John P. Sundberg, Lloyd E. King, Jr, and Raoul V. Kuiper11 Mammary Gland 213Alexander D. Borowsky and Robert D. Cardiff12 The Respiratory Tract 237Jerrold M. Ward and John P. Sundberg13 The Gastrointestinal Tract 259Jerrold M. Ward, Piper M. Treuting, and M. Kay Washington14 Cardiovascular System 284Kathleen L. Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy K. Cooper15 Liver and Pancreas 307Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger16 Neuromuscular System 336Peter Vogel, Laura J. Janke, and Heather W. Sheppard17 Endocrine System 355Krista M. D. La Perle18 Kidney and Urinary Bladder 378Jeffrey B. Kopp, Avi Z. Rosenberg, Cory F. Brayton, Jeffrey I. Everitt, and Jerrold M. Ward19 Female Reproductive System 403Darlene Dixon and Alexander Yu. Nikitin (In Memory of Dr. Joel Mahler)20 Male Reproductive System 431Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, and Robert D. Cardiff21 Nervous System 462Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli22 Eye and Ear 493Heather W. Sheppard, Laura J. Janke, Jerold E. Rehg, and Peter Vogel23 Bones and Teeth 520Peter Vogel, John P. Sundberg, and Cheryl Ackert-BicknellIndex 541

O autorze

The editorsJohn P. Sundberg, DVM, PhD, DACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA.Peter Vogel, DVM, PhD, DACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children's Research Hospital in Memphis, Tennessee, USA.Jerrold M. Ward, DVM, PhD, DACVP, FIATP,is an Adjunct Faculty member at The Jackson Laboratory, Bar Harbor, Maine, USA and Adjunct Professor in the Department of Biomedical Sciences at Cornell University College of Veterinary Medicine in Ithaca, New York, USA.