Pathogenicity and Drug Resistance of Human Pathogens: Mechanisms and Novel Approaches

ISBN-13: 9789813294486 / Angielski / Twarda / 2020 / 404 str.

Saif Hameed; Zeeshan Fatima

Spis treści

Chapter 1. Pathogenicity and Drug resistance in Mycobacterium tuberculosis.- Chapter 1.1. Overview of tuberculosis pathogenesis.- Chapter 1.2.  Response of Mycobacterium Tuberculosis to pH stress.- Chapter 1.3. Recent advances in Diagnosis of Tuberculosis.- Chapter 1.4. Molecular basis of Drug Resistance in Mycobacteria.- Chapter 1.5. Eliminating Mycobacterial persisters: novel targets for anti-TB therapy.- Chapter 1.6. Roadmap for the eradication of MDR-TB.- Chapter 2. Candida infections and therapeutic strategies.- Chapter 2.1. Fungal diseases and their treatment: a holistic approach.- Chapter 2.2. Anti-Candida therapeutics: mechanisms, resistance and safer phytomedicinal approaches.- Chapter 2.3. Mitochondria and drug resistance in Candida.- Chapter 2.4. Mechanism of Anti-Fungal for cutaneous infections: preventive potential, mechanism and treatment.- Chapter 3. Malarial parasite biology.- Chapter 3.1. Drug targets in Malarial parasites.- Chapter 3.2. Pathogenic mechanism and signaling pathways in Plasmodium.- Chapter 3.3. Mechanism of Drug Resistance in Plasmodium.- Chapter 3.4. Novel antimalarial drug targets.- Chapter 3.5. Novel therapeutic targets in malaria.- Chapter 4. Emerging Viral Diseases.- Chapter 4.1. Hepatitis C Virus and innate interferon response.- Chapter 4.1.1. Pathogen biology.- Chapter 4.1.2. Drug resistance.- Chapter 4.1.3. Novel drug targets and therapeutic strategies.- Chapter 4.2. Epidemiological trends and current challenges in Ebola.- Chapter 4.2.1. Pathogen biology.- Chapter 4.2.2.Drug resistance.- Chapter 4.2.3. Novel drug targets and therapeutic strategies.- Chapter 4.3. Prions diseases: a concern for mankind.- Chapter 5. Translational Research in Human Microbes.- Chapter 5.1. Harnessing microbiota as anti-infectives.- Chapter 5.2. Human microbiome and malignancy: principles, mechanisms and challenges.- Chapter 5.3. Current and future perspectives of nanobiotechnology: in combating microbial pathogenesis.- Chapter 5.4. Microbes in reproductive tract system: inferences from microbial world.- Chapter 5.5. miRNAs in infectious diseases.- Chapter 5.6. Application of bioinformatics in combating infectious diseases.

O autorze

Dr. Saif Hameed is currently Associate Professor at Amity Institute of Biotechnology, Amity University Haryana. Dr. Hameed did his Bachelors from University of Delhi and Masters from Jamia Hamdard with distinction in 2003 and 2005 respectively. He completed his doctoral studies in Life Sciences from Jawaharlal Nehru University in 2010 where he also received CSIR Research Associateship for the one year postdoctoral work. He also worked as Visiting Scholar in Institute für Mikrobiologie, Heinrich-Heine-Universität, Düsseldorf, Germany in 2008. Dr. Hameed has received Young Scientist award from Science and Engineering Research Board, Department of Science and Technology, New Delhi in the year 2012. Dr. Hameed is actively engaged in research in the field of infectious diseases related to multidrug resistance (MDR) in pathogenic fungi. He has around 40 peer-reviewed papers to his credit in both international and national journals of repute, 2 books, 15 book chapters along with 22 popular articles with 2 of them as ‘cover story’. He has successfully convened 7 national conferences as Organizing Secretary. He has guided 2 Ph.D. students for their doctoral degrees and supervised 20 UG & PG level students for their research projects. He is life member of Association of Microbiologist of India (AMI) and International Society for Infectious Diseases (ISID).

 

Dr. Zeeshan Fatima is currently working as Associate Professor at Amity Institute of Biotechnology, Amity University Haryana. Dr. Fatima did her Bachelors and Masters from Banaras Hindu University in 2000 and 2002 respectively. She earned her doctoral degree in Biochemistry from Aligarh Muslim University in 2008. She has held research positions under nationally and internationally funded research projects which also include her Research Associateship at B.H.U. and J.N.U. and postdoctoral training from University of Cincinnati, Ohio, USA in 2010. Dr. Fatima has received two Young Scientist awards under Fast Track and Women Scientist Schemes respectively from Science and Engineering Research Board, Department of Science and Technology, New Delhi in the year 2012.  She has also bagged regular projects for funding from DBT, Board of Research in Nuclear Sciences (BRNS), BARC Mumbai and Ministry of AYUSH, New Delhi. She is actively engaged in research in the field of infectious diseases and particularly on the aspect of Multidrug resistance in human pathogen Mycobacterium tuberculosis and Candida albicans. She has 2 books and around 35 peer-reviewed papers to her credit in both international and national journals of repute. She participated in several international and national conferences and received various accolade in the form of best paper awards. She has successfully convened 5 national conferences as Organizing Secretary and organized many guest lectures. She has supervised 2 Ph.D. students and guided 21 UG & PG level students for their research projects. She is life member of Association of Microbiologist of India (AMI) and International Society for Infectious Diseases (ISID).

Blurb

The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases.

Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases.

In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.