Pathogenicity Islands and the Evolution of Pathogenic Microbes: Volume I

ISBN-13: 9783642076565 / Angielski / Miękka / 2010 / 234 str.

J. Hacker; J. B. Kaper

Opis

It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

Recenzje

From the reviews:

"In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ... This compendium ... features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants." (Susanne Rohrer, BioWorld, Issue 6, 2002)

Spis treści

Evolution of prokaryotic genomes.-Extraintestinal Escherichia coli as a model system for the study of pathogenicity islands.-Pathogenicity islands fo intestinal E. coli.-Pathogenicity islands of Shigella.-Pathogenicity islands and host adaptation of Samonella serovars.-Plasmids and pathogenicity islands of Yersinia.-Genomic structure of LPS-specific loci.-Genomic structure of capsular determinants.-Genome Plasticity of Pathogenic and Non-Pathogenic Enterobacteria.-Phylogenetic Relationships and Virulence Evolution in the Genus Bordetella.-Pathogenicity Islands and PAI-Like Structures in Pseudomonas Species.-Subject Index

O autorze

Jörg Hacker ist Professor für Mikrobiologie und leitet das Institut für Molekulare Infektionsbiologie der Uni Würzburg.