Pathogenesis and Treatment of Diabetes Mellitus

ISBN-13: 9789401084116 / Angielski / Miękka / 2011 / 188 str.

J. K. Radder; H. H. P. J. Lemkes; H. M. J. Krans

Opis

In this book on diabetes mellitus both the pathogenesis and treat- ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol- ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre- disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto- immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out- break of the disease, the destructive process has already been active for years.

Spis treści

1.: Pathogenesis of Diabetes Mellitus.- Section 1.1.: Type I Diabetes Mellitus.- 1.1.1.: Introduction: Type I Diabetes Mellitus.- 1.1.2.: Autoimmune pathogenesis of viral diabetes.- 1.1.3.:Immunological features of insulin-dependent diabetes mellitus.- 1.1.4.:Genetic counselling in Diabetes Mellitus.- Section 1.2.: Type II Diabetes Mellitus.- 1.2.1.: Introduction: Pathogenesis of type II Diabetes Mellitus.- 1.2.2.:Insulin secretion in noninsulin-dependent Diabetes Mellitus.- 1.2.3.: Insulin antagonism.- 1.2.4.: The contribution of the central nervous system to the regulation of insulin release and the stabilization of blood glucose.- 1.2.5.: Cellular insulin resistance.- 2.: Treatment of Diabetes Mellitus.- Section 2.1.: Diet and hypoglycaemic agents.- 2.1.1.: Introduction: Diet and hypoglycaemic agents.- 2.1.2.: Diet and Diabetes.- 2.1.3.: Oral hypoglycaemic drugs.- Section 2.2.: Insulin.- 2.2.1.: Introduction: Insulin treatment.- 2.2.2.: Hyperinsulinaemia.- 2.2.3.: Insulin: The physiological basis of its administration.- 2.2.4.: Diabetes Technology: From the pump to the microprocessor.- Section 2.3.: Pancreas transplantation.- 2.3.1.: Introduction: Pancreas transplantation.- 2.3.2.: Current state of pancreas transplantation.- Index of subjects.