Particulate Interactions in Dry Powder Formulation for Inhalation

ISBN-13: 9780367397975 / Angielski / Miękka / 2019 / 264 str.

Xian Ming Zeng; Gary Peter Martin; Christopher Marriott

Opis

Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).

Spis treści

1. Interparticulate Forces 2. Interparticulate Forces in Pharmaceutical Powders 3. Medicinal Aerosols 4. Particle Interactions with Air Streams 5. Particulate Interactions in Dry Powder Aerosols 6. Measurement of Cohesion, Adhesion and Dispersion of Powders 7. Physical Characterisation of Pharmaceutical Powders

O autorze

Zeng, Xian Ming; Martin, Gary Peter; Marriott, Christopher