Parkinson's Disease and Related Disorders

ISBN-13: 9783211289273 / Angielski / Twarda / 2006 / 506 str.

Peter Riederer; Heinz Reichmann; Moussa Youdim

Opis

This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives."

Spis treści

Oleh Hornykiewicz.- Melvin Yahr (1917–2004). An appreciation.- Melvin D. Yahr, 1917–2004. A personal recollection.- Melvin D. Yahr, 1917–2004. A personal recollection.- Pathology.- The discovery of dopamine deficiency in the parkinsonian brain.- Synchronizing activity of basal ganglia and pathophysiology of Parkinson’s disease.- Basal ganglia discharge abnormalities in Parkinson’s disease.- Bad oscillations in Parkinson’s disease.- Cortical muscle coupling in Parkinson’s disease (PD) bradykinesia.- GDNF as a candidate striatal target-derived neurotrophic factor for the development of substantia nigra dopamine neurons.- The engrailed transcription factors and the mesencephalic dopaminergic neurons.- The role of Pitx3 in survival of midbrain dopaminergic neurons.- Genetic analysis of dopaminergic system development in zebrafish.- Striatal plasticity in parkinsonism: dystrophic changes in medium spiny neurons and progression in Parkinson’s disease.- The nigrostriatal DA pathway and Parkinson’s disease.- Relationship between axonal collateralization and neuronal degeneration in basal ganglia.- Pathology associated with sporadic Parkinson’s disease — where does it end?.- Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson’s disease.- A short overview on the role of ?-synuclein and proteasome in experimental models of Parkinson’s disease.- The role of protein aggregates in neuronal pathology: guilty, innocent, or just trying to help?.- Iron and neuromelanin.- New face of neuromelanin.- The effect of neuromelanin on the proteasome activity in human dopaminergic SH-SY5Y cells.- Potential sources of increased iron in the substantia nigra of parkinsonian patients.- Iron and Friedreich ataxia.- Genetics.- Nongenetic causes of Parkinson’s disease.- Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?.- CYP450, genetics and Parkinson’s disease: gene × environment interactions hold the key.- Unique cytochromes P450 in human brain: implication in disease pathogenesis.- Cytochrome P450 and Parkinson’s disease: protective role of neuronal CYP 2E1 from MPTP toxicity.- Nicotine induces brain CYP enzymes: relevance to Parkinson’s disease.- Genetic causes of Parkinson’s disease: extending the pathway.- Progress in familial Parkinson’s disease.- Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins.- Parkin and defective ubiquitination in Parkinson’s disease.- PINK-1 and DJ-1 — new genes for autosomal recessive Parkinson’s disease.- Clinical and pathologic features of families with LRRK2-associated Parkinson’s disease.- Molecular genetic findings in LRRK2 American, Canadian and German families.- Imaging.- Genetic and DAT imaging studies of familial parkinsonism in a Taiwanese cohort.- Neuroimaging in Parkinson’s disease.- Transcranial sonography in the early and differential diagnosis of Parkinson’s disease.- Models.- How to judge animal models of Parkinson’s disease in terms of neuroprotection.- Limitations of cellular models in Parkinson’s disease research.- The Rotenone model of Parkinsonism — the five years inspection.- Controversies on new animal models of Parkinson’s disease Pro and Con: the rotenone model of Parkinson’s disease (PD).- Proposed animal model of severe Parkinson’s disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum.- ?-Synuclein overexpression model.- Kynurenines, Parkinson’s disease and other neurodegenerative disorders: preclinical and clinical studies.- Clinical approaches.- What’s new? Clinical progression and staging of Parkinson’s disease.- Parkinson’s disease: premotor clinico-pathological correlations.- Detection of preclinical Parkinson’s disease along the olfactory trac(t).- The clinical approach to gait disturbances in Parkinson’s disease; maintaining independent mobility.- Getting around and communicating with the environment: visual cognition and language in Parkinson’s disease.- Cardiovascular aspects of Parkinson disease.- Multiple system atrophy and autonomic failure.- Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview.- Sleep and wakefulness disturbances in Parkinson’s disease.- Neuroinflammation.- Parkinson’s disease dementia: what’s in a Lewy body?.- Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of Interleukin 10.- Role of cytokines in inflammatory process in Parkinson’s disease.- Neurosurgery.- Surgical therapy for Parkinson’s disease.- Deep brain stimulation for the treatment of Parkinson’s disease.- Deep brain stimulation in Parkinson’s disease patients: biochemical evidence.- Neurosurgery in Parkinson’s disease: the doctor is happy, the patient less so?.- L-Dopa.- Placebo effect and dopamine release.- A new look at levodopa based on the ELLDOPA study.- Thirty five years of experience in the treatment of Parkinson’s disease with levodopa and associations.- Neuroprotection.- Concerning neuroprotective therapy for Parkinson’s disease.- Triggering endogenous neuroprotective mechanisms in Parkinson’s disease: studies with a cellular model.- Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression.- M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson’s disease.- Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety.- Other treatment strategies.- Anti-apoptotic gene therapy in Parkinson’s disease.- The discovery of the pressor effect of DOPS and its blunting by decarboxylase inhibitors.- Dystonia.- Pathophysiology of dystonia.- Genetics of dystonia.