Parkinsonism and the Environment

ISBN-13: 9783030874537 / Angielski / Miękka / 2023 / 158 str.

Nikolay M. Filipov

Opis

“The book is comprised of individual reviews with the common goal of providing up-to-date state of the knowledge information on the role the environment plays in the pathogenesis of parkinsonism. The reviews focus on recent advances in the quest of deciphering the molecular and cellular mechanisms of parkinsonian dysfunction, highlight specific emerging dopaminergic toxicants and an alternative experimental model to study the link between environmental exposures and parkinsonism, and provide an update from epidemiological and experimental points of view related to the pesticide exposures and parkinsonism/Parkinson’s Disease association. Foremost experts in their respective fields are the senior authors on each chapter and the book fills a critical void that now exists as a book of similar nature has not been published in the last 15 years. Researchers and clinicians with an interest in Parkinson's Disease and related disorders, as well as toxicologists, graduate students, and the general public who are interested in the contribution of environmental factors to neurological dysfunction are among the readership for this book.”

Spis treści

Experimental evidence for pesticide contribution in the pathogenesis of Parkinsonism: an update.- Epidemiological evidence for pesticide involvement in the etiology of Parkinson’s Disease: current state of affairs?”.- Manganese induced Parkinsonism: cellular and molecular mechanisms.- Manganese overexposures in occupational and environmental settings and Parkinsonism: where do we stand.- Aberrant dopamine metabolism as a focal point in the mechanism of environmental contaminant-induced dopaminergic dysfunction.- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs.- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs.- Protein kinase C-delta (PKC-delta): a major molecular target for disparate dopaminergic toxicants.- Environmental contribution to redox dyshomeostasis in Parkinsonism.

O autorze

Dr. Filipov is a Professor in the Department of Physiology and Pharmacology of the University of Georgia. He is also part of the university’s Interdisciplinary Toxicology and Neuroscience programs. His research is focused in large part on the role certain pesticides and metals play in the pathogenesis of basal ganglia disorders of parkinsonian nature