Pancreatic Disease: State of the Art and Future Aspects of Research

ISBN-13: 9783540653578 / Angielski / Miękka / 1999 / 272 str.

Paul G. Lankisch; E. P. Dimagno; Eugene P. Dimagno

Opis

In the past several years much progress has been made in understanding the basic mechanisms of pancreatic physiology and the pathogenesis, diagnosis, and treatment of pancreatic disease. A symposium took place in Munich on 18-19 September 1998 that aimed at summarizing current knowledge of the exocrine pancreas and giving di rection to future research. It targeted all practitioners and scientists working in the field of exocrine pancreatic disease. The symposium was also designed to stimulate young persons embarking on a career in this area. It was an exciting meeting for all of us. We wish to extend our thanks to all participants for their prompt submission of manuscripts and to Springer Verlag for speedy publication, providing us with an up-to-date volume on pancreatic research. We would also like to thank G. Beyendorff-Hajda and W. Glockner, as well as D. Kriiger, representatives of Knoll Deutschland GmbH, for their organiza tional assistance and Knoll itself for its generous sponsorship, which enabled colleagues from other countries to participate and made publication of the symposium possible."

Spis treści

I Acute Pancreatitis.- 1 Acute Pancreatitis: Mechanisms of Cell Injury — Genetics.- 2 Events Inside the Pancreatic Acinar Cell in Acute Pancreatitis: Role of Secretory Blockade, Calcium Release and Dehydration for the Initiation of Trypsinogen Activation and Autodigestion.- 3 Immunologic Mechanisms in Acute Pancreatitis.- 4 Mechanisms in Cellular Injury.- 5 Acute Pancreatitis: Bacterial Translocation and Pancreatic Infections.- 6 Staging and Early Nasolateral Feeding in Acute Pancreatitis.- 7 Acute Pancreatitis: Medical and Endoscopic Treatment.- 8 Surgical Treatment of Acute Pancreatitis.- II Chronic Pancreatitis.- 9 Chronic Pancreatitis: Do Different Etiologies (Alcohol, Obstruction) Invoke Different Mechanisms.- 10 Exocrine Pancreatic Secretion, Pain, and Malabsorption.- 11 Intestinal Transit of Chyme and its Regulatory Role: Clinical Implications.- 12 Treatment of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis.- 13 Mechanisms of Fibrosis and Potential Antifibrotic Agents.- 14 Mechanisms of Pain and its Medical Management, Including Neurolytic Treatments.- 15 Endoscopic Treatment of Pain and Complications of Chronic Pancreatitis.- 16 Surgical Treatment of Chronic Pancreatitis.- III Cystic Fibrosis.- 17 Genetics and Molecular Pathology of Cystic Fibrosis.- 18 Treatment of Gastrointestinal Manifestations in Cystic Fibrosis.- 19 Is Idiopathic Chronic Pancreatitis Cystic Fibrosis.- IV Pancreatic Cancer.- 20 Growth Factors and Transcription Factors in Pancreatic Cancer.- 21 Biological Approaches to the Therapy of Pancreatic Cancer.- 22 Pancreatic Cancer: Preclinical Development of an Experimental Treatment Strategy Using Retinoids and Interferon-alpha.- 23 Aspects of Radical Surgery for Exocrine Cancer of the Pancreatic Head.- V Epidemiology.- 24 Lessons Learned about Pancreatitis and Pancreatic Cancer from Epidemiological Studies.

Blurb

This symposium volume summarizes the latest research, research that has greatly advanced our understanding of both the basic mechanisms of pancreatic physiology and pathophysiology and the diagnosis and treatment of the diseases of the exocrine pancreas. By doing so, it serves to give direction to future research. Diseases discussed include acute and chronic pancreatitis, cystic fibrosis, and pancreatic cancer. The volume also reflects a central concern of the symposium: to stimulate young persons embarking on a career in this area.