1. Introduction: principles and practices for small tissue samples in the diagnosis of pancreatic masses Brian Morse and Junsung Choi; 2. Endoscopic ultrasound-guided fine-needle aspiration of the pancreas Abdurrahman Kadayifci and William R. Brugge; 3. Tissue handling and processing; 4. Ancillary studies; 5. Cytology and histology of the normal pancreas, and contaminants; 6. Non-neoplastic mass lesions; 7. Cystic lesions; 8. Pancreatic ductal adenocarcinoma and variants; 9. Solid nonductal epithelial neoplasia; 10. Secondary neoplasia (metastases, direct extension of adjacent tumors, and lymphoreticular lesions); 11. Mesenchymal neoplasia; Index.