Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery

ISBN-13: 9780367446734 / Angielski / Miękka / 2019 / 968 str.

Chas Bountra; Rajesh Munglani; William K. Schmidt

Opis

This book focuses on basic aspects, clinical aspects, and novel approaches to drug discovery. It deals with major advances in understanding the basic pathophysiology of pain and how it can be manipulated at the anatomical, physiological immunological, pharmaceutical, and psychological levels.

Spis treści

Part 1: Basic Aspects 1. Mechanism-Based Classifications of Pain and Analgesic Drug Discovery 2. Sites of Analgesic Action 3. From Acute to Chronic Pain: Peripheral and Central Mechanisms 4. Central and Peripheral Components of Neuropathic Pain 5. A New Perspective on Signal Transduction in Neuropathic Pain: The Emerging Role of the G Protein βγ Dimer in Transducing and Modulating Opioid Signaling 6. Pain and the Somatosensory Cortex 7. Descending Pathways in Spinal Cord Stimulation and Pain Control 8. Local Neuroimmune Interactions in Visceral Hyperalgesia: Bradykinin, Neurotrophins, and Cannabinoids 9. Pain Processing in the Periphery: Development of Analgesics Part 2: Clinical Aspects 10. Neuroimaging of Pain: Possibilities of Objective Measurements of Analgesic Actions in Human Subjects 11. Surrogate Models of Pain 12. Acute Trauma and Postoperative Pain 13. Effectiveness of Needling Techniques with Special Reference to Myofascial Pain Syndromes 14. Advances in the Management of Spinal Pain and Radiofrequency Techniques 15. Pulsed Radiofrequency Treatment of Chronic Neck, Back, Sympathetic, and Peripheral Neuroma-Derived Pain 16. Spinal Cord Stimulation 17. Spinal Endoscopy: Its Current Status and Role in Lumbosacral Radiculopathy 18. Cancer Pain Treatment 19. Inflammatory Joint Disease and Pain 20. Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen, Pelvis, and Bladder and Chronic Urogenital and Rectal Pain 21. Nerve Injury Pain 22. Sympathetically Maintained Pain 23. Headache: Basic Anatomy and Physiology of the Trigeminovascular System 24. Psychological Factors in Measurement of Pain 25. Challenges and Pitfalls of Clinical Trials: Evaluating Novel Analgesics for Neuropathic Pain Part 3: Novel Approaches to Drug Discovery 26. Molecular Approaches to the Study of Pain 27. Molecular Validation of Pain Targets 28. Genetics of Pain 29. Animal Models of Pain Part 4: New and Emerging Therapies 30. An Overview of Current and Investigational Drugs for the Tre