Oxygen Free Radicals in Tissue Damage

ISBN-13: 9781461598428 / Angielski / Miękka / 2013 / 297 str.

M. Tarr; F. Samson

Opis

Oxygen free radicals and other reactive oxygen species are being postulated as causal agents in an increasing number of pathological conditions. Indeed, some investigators are suggesting that highly destructive reactive oxygen species are the final common path lead- ing to tissue damage following a wide variety of insults including trauma, hypoxia, ischemia, hyperoxia, radiation, some toxins, and even strenuous athletic pursuits. But, as Robert Floyd points out, "Proof of the importance of oxygen free radicals and the oxidative damage they initiate depend on unequivocal evidence for the pres- ence of free radicals and a clear association of their formation with the induction of the dysfunction of pathological conditions. " Since such proof does not come easily, there have been and will continue to be many controversies regarding the role played by reactive oxygen species in tissue damage. There have been many recent reviews of the chemistry and pos- sible role of reactive oxygen species in many types of organ dys- functions, tissue damage, degenerative diseases, and aging. This book is not such a review. Rather it presents for a diverse audience of physical-organic chemists, biochemists, medical researchers, and other investigators of pathophysiology, discussions of a variety of is- sues important for understanding reactive oxygen species and their role in tissue damage.

Spis treści

1. Getting Along with Oxygen.- 2. Oxygen Free Radicals and Tissue Injury.- 3. Photosensitizers as Model Systems to Study Reactive Oxygen Effects in Biological Preparations.- 4. Singlet Oxygen in Biological Systems: A Comparison of Biochemical and Photochemical Mechanisms for Singlet Oxygen Generation.- 5. In Vivo Detection of Oxygen Free Radical Species.- 6. Reactive Oxidant Species in Rat Brain Extracellular Fluid.- 7. Oxygen Radicals Mediate Ischemia-Reperfusion-Induced Leukocyte-Endothelial Cell Adhesive Interactions.- 8. The Respiratory Burst and Drug Metabolism: Implications for Idiosyncratic Drug Reactions and Antiinflammatory Effects.- 9. Role of Oxygen Radicals in Central Nervous System Trauma.- 10. Nitric Oxide as a Mediator of Cerebral Blood Flow, Synaptic Plasticity, and Superoxide-Mediated Brain Injury.- 11. Contributions of the Physical Properties of Neuroprotective Agents to their Efficacy as Inhibitors of Lipid Peroxidation.- 12. Oxidative Stress in the Pathogenesis of Postischemic Ventricular Dysfunction (Myocardial “Stunning”).- 13. Oxygen Free Radicals in the Pathophysiology of Myocardial Ischemia/Reperfusion.- 14. Reactive Oxygen-Induced Modifications of Cardiac Electrophysiology: A Comparison of the Effects of Rose Bengal and other Reactive Oxygen Generators.