Oxidative Stress in Aging: From Model Systems to Human Diseases

ISBN-13: 9781588299918 / Angielski / Twarda / 2008 / 320 str.

Satomi Miwa; Kenneth Bruce Beckman; Florian Muller

Opis

Oxidative Stress in Aging: From Model Systems to Human Diseases discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). Human aging is a complex phenomenon - not everyone gets the same diseases and dies from the same cause. Accumulating reports implicate the connection between free radicals and various diseases and age-related pathological conditions. Although the causal relationships have not been established, it is necessary to discuss how free radicals are involved in each situation. In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.

Spis treści

Chapter 1. Introduction to the Free Radical Theory of Aging Chapter 2. Reactive Oxygen Species, Antioxidant Defence and Repair/Removal of Damage Chapter 3. (Technical Considerations for Experiments) Chatper 4. Fibroblast Chapter 5. Podospora Chapter 6. Yeast Chapter 7. C. Elegans Chapter 8. Drosophila Chapter 9. Mice Chapter 10. Rhesus Monkeys Chapter 11. Comparative Biology of Vertebrate Lifespans Chapter 12. Diabetes Chapter 13. Alzheimer's Disease, Parkinson's Disease Chapter 14. Atherosclerosis Chapter 15. Ischemia Reperfusion Chapter 16. Effect of Antioxidant Enzyme Manipulation on Ischemia, reperfusion in Mice Chapter 17. Immune Dysfunction Chapter 18. Cancer Chapter 19. Epidemiological review of the major pharmacological interventions trials Chapter 20. Possible Reasons why Antioxidant Supplements Do not Work