Oxidation: The Cornerstone of Carcinogenesis: Oxidation and Tobacco Smoke Carcinogenesis. a Relationship Between Cause and Effect

ISBN-13: 9789048177028 / Angielski / Miękka / 2010 / 258 str.

John C. Stavridis

Opis

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.

Recenzje

"The book "Oxidation: The Cornerstone of Carcinogenesis" by Professor J. C. Stavridis represents a monumental work of correlating oxidation as the common pathway of causing cell damage to the bronchoepithelial cells and carcinogenesis utilized by the various tobacco smoke constituents. ...
This book by Prof. Stavridis is a significant intellectual feat of the first order, bringing original insights and a comprehensive review of an area that heretofore had been unaccountably neglected." (Dr. Constantine Karakousis, Professor of Surgical Oncology)

"In the first page of the book the author states: "It is important to understand the properties of dioxygen since oxidation reactions using it power not only our bodies but our entire civilization"....
Written by an expert, this book does not merely address an emerging topic, but additionally it fills a void by analytically and expansively linking oxidation and carcinogenesis and providing knowledge and information to researchers and other stakeholders of scientific knowledge. I welcome the insights presented in the book and intend to include it among the reference books I provide to my students of risk assessment and management." (Dr. Demetrios J. Moschandreas, Professor of Environmental Engineering)

Spis treści

Chapter 1: Oxygen and Nitrogen free radicals Chapter 2: Oxidative stress Chapter 3: Oxidative damage of genome DNA: repair mechanisms Chapter 4: Mitochondria: structure, function and relationship with carcinogenesis Chapter 5: Oxidative activation of transcription factor pathways by cigarette smoke oxidants Chapter 6: Cell protection mechanisms from oxidation Chapter 7: Role of DNA adducts in carcinogenesis Chapter 8: Transmolecular reactions of genetic toxicity: alkylation and methylation of DNA Chapter 9: Toxicity and carcinogenicity of hydrocarbons Chapter 10: Toxicity and carcinogenicity of the aromatic hydrocarbons Chapter 11: Toxicity and carcinogenicity of aldehydes Chapter 12: Toxicity and carcinogenicity of the nitriles Chapter 13: Toxicity and carcinogenicity of the eterocyclic organic compounds Chapter 14: Toxicity and carcinogenicity of metals Chapter 15:Oxidative profile of cigarette smoke and lung cancer Chapter 16: Smoking and lung cancer

O autorze

John C. Stavridis is a medical doctor who studied Medicine at the Military Medical School of Thessaloniki, Greece. He specialized in Internal Medicine at the Evangelismos Medical Centre, Athens, and received his MD and Professorship from the University of Athens Medical School. Following a postdoctoral position as a senior research fellow and registrar at postgraduate Medical School, London University, Hammersmith Hospital, Department of Clinical Hematology, he joined the Hematology Unit at St. Sabbas Anticancer Hospital, Athens, as director. He taught Physiology from 1991-1999 as a head of the Department of Physiology and full professor at the University of Athens Medical School. Since 1999, Prof. Stavridis has been President of the Institute of Biomedical Research and Biotechnology, Athens.