Oxidant-Antioxidant Status : Mechanism of Action and Biochemical Parameters in Patients with Sickle Cell Disease

ISBN-13: 9783330069572 / Angielski / Miękka / 2017 / 88 str.

Eman Refaat

Opis

It is inherited in an autosomal co dominant manner. Sickle cell disease is caused by point mutation in the beta-Globin gene on chromosome 11, causing replacement of glutamic acid by valine at the sixth position of beta globin chain of Hb The altered amino acid content in beta-globin chain promotes the non-covalent polymerization (aggregation) of haemoglobin causing red blood cells to become sickle shaped and this decreases the elasticity of RBCs which is more pronounced during conditions of decreased oxygenation or higher oxygen demand as at higher altitude, infections, exercises and during surgery.

O autorze

Dr. Eman Refaat Youness, MD, Medical Biochemistry, Faculty of Medicine, Cairo university, Assistant professor of medical Biochemistry, National Research centre, Egypt, Experienced in experimental design, clinical Researches, have a lot of international publications, member in international societies, Reviewer and editor in many journals.