Overcoming Resistance to Egfr Inhibitors in Egfr-Mutant Nsclc: Volume 19

ISBN-13: 9780128228333 / Angielski / Twarda / 2023

Anthony Faber

Spis treści

1. The EGFR in NSCLC: Biology, activation and targeting2. Background of the EGFR receptor, biology of activation, regulation of EGFR in normal cells and cancer cells, mutations as oncogenic in NSCLC3. Background of EGFR inhibitor development and implementation, assessment of how EGFR inhibitors have been implemented and are currently implemented4. YAP signalling in EGFR inhibitor resistance5. Apoptosis resistance in EGFR inhibitor resistance6. EGFR mutations and resistance to EGFR inhibitors7. SCLC transformation and resistance to EGFR inhibitors8. EMT and resistance to EGFR inhibitors in EGFR mutant NSCLC9. Intratumoral heterogeneity and resistance10. Clinical trials of EGFR inhibitors in EGFR mutant lung cancer11. Methodology of the detection of resistant mechanisms in the lung cancer clinic