Osteoporotic Fracture and Systemic Skeletal Disorders: Mechanism, Assessment, and Treatment

ISBN-13: 9789811656156 / Angielski / Miękka / 2022 / 576 str.

Hideaki E. Takahashi; David B. Burr; Noriaki Yamamoto

Opis

This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional trainees and practitioners in health and social care fields who care for and treat the elderly.Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of “Remodeling” and “Modeling” is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects of various drugs used to treat osteoporosis at both material and structural levels of bone and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are includedTreatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.

Spis treści

​Part I　Bone Morphometry, and Radiological Assessment.- 1. Past, Present and Future of Bone Histomorphometry .- 2. Effects of aging on bone fragility.-3. Cellular and molecular biology in bone remodeling.- 4. Modeling and Modeling-based bone formation in trabecular packets.- 5. A role of canopy and reversal cells in bone remodeling.- 6. Significance of reversal-resorption phase in cortical porosity.- 7. A role of focal osteoporosis defects in hip fracture.- 8. Bone Tissue and its mechanical regulation.- 9. Minimodeling, modeling-based formation, in human trabeculae and bone.- 10.　Fracture healing and cause of non-union.- 11. Disturbance of osteonal remodeling in atypical femoral fracture.- 12. Microcrack and microdamage.- 13. 3D microstructure of bone tissue 14. 3D bone morphometry.- 15. DXA and SQ assessment of osteoporosis.- 16. Assessment of osteoporosis by HR-pQCT, QCT, MRI.- 17.　FRAX  (John A. Kanis).- Part II Metabolic and Systemic Disorders and Bone.- 18. Skeletal disorders on Hypovitamin D.- 19.　Diabetes and bone.- 20.　CKD-MBD.- 21. Ehlers-Danlos Syndrome, IgG4 related disorders and Hepatitis type C.- Part III　Medical and Conservative Treatment.- 22. Effects of Osteoporosis Drugs – BMD and Morphological Assessment.-23. Vibration as an exercise modality to prevent sarcopenia.- Part IV Operative Treatment.- 24. Operative treatment of hip fracture.- 25. Balloon Kyphoplasty.- 26. Operative treatment of spinal disorders with consideration of dynamic axis of spinal column and lower extremities.- 27. Operative treatment of spinal disorders with minimum invasive technique.

O autorze

Hideaki E. Takahashi, MD, PhD

Professor Emeritus, Niigata University

Former Chair, Orthopaedic Department Niigata University

President Emeritus, Niigata University of Health and Welfare

Consultant, Niigata Bone Science Institute

David B. Burr, PhD, FAAA

Distinguished Professor, Indiana University

Associate Vice Chancellor for Research, IUPUI

 Dept. of Anatomy and Cell Biology

Dept. of Biomedical Engineering

Indiana University School of Medicine

Noriaki Yamamoto, MD, PhD

Director, Niigata Rehabilitation Hospital

Head, Orthopaedic Department, Niigata Rehabilitation Hospital

Director, Niigata Bone Science Institute

Secretary General, NPO Fragility Fracture Network-Japan