Osteoporosis in Men: The Effects of Gender on Skeletal Health

ISBN-13: 9780123746023 / Angielski / Twarda / 2009 / 741 str.

Eric S Orwoll

Opis

Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger - 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

• Brings together more eminent investigators and clinicians to interpret developments in this growing field.
• Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.
• There is no book on the market that covers osteoporosis in men as comprehensively as this book.

Recenzje

"The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows." --Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom

"The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field." -- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA

"This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis." --Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy

Spis treści

Section 1 Essentials of bone biology 1. The Biochemistry of Bone: Composition and Organization 2. Bone Remodeling: Cellular Activities in Bone 3. Assessment of Bone Turnover Using Biochemical Markers 4. Fundamentals of Mineral Homeostasis 5. The Mechanical Properties of Bone 6. Assessment of Bone Architecture

Section 2 Development and growth of the male skeleton 7. Skeletal Growth in Males 8. Pubertal Growth of the Male Skeleton 9. The Effects of Sex Steroids on Bone Growth 10. Nutritional Basis of Skeletal Growth 11. Physical Activity and Skeletal Growth

Section 3 Skeletal genetics 12. The Genetics of Peak Bone Mass

Section 4 Aging and the male skeleton 13. Age-Related Changes in Bone Remodeling and Micro Architecture 14. Markers of Bone Remodeling and the Aging Skeleton 15. Alterations in Mineral Metabolism in the Aging Male 16. Change in Bone Size and Geometry with Aging 17. Aging and Bone Density 18. The Effect of Age on Material Properties

Section 5 Nutritional issues 19. Calcium, Bone Strength and Fractures 20. Vitamin D and Bone 21. Role of Dietary Protein in Bone Growth and Bone Loss

Section 6 Sex steroids and the skeleton in men 22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes 23. Estrogen and the Skeleton - Rodents 24. Estrogen and the Skeleton - Humans 25. Androgens and the Skeleton - Animal Models 26. Androgens and the Skeleton - Humans 27. Androgen Effects on the Skeletal Muscle

Section 7 Fractures in men 28. Epidemiology of Fractures 29. Individualized Progress of Fractures in Men 30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men 31. Economic Impact of Osteoporotic Fractures (vs women) 32. Adverse Health Outcomes in Men with Osteoporosis

Section 8. Metabolic bone disease in men 33. Idiopathic Osteoporosis 34. Glucocorticoid Induced Osteoporosis 35. Testicular Dysfunction 36. Alcohol and Bone 37. Transplantation Osteoporosis 38. Management of Fractures in Men with Impaired Renal Function 39. Hyperparathyroidism 40. Hypercalciuria 41. The Skeletal Phenotype of the Male Athlete 42. Inherited and Related Disorders of Bone Matrix Synthesis in Men

Section 9 Diagnostic approach 43. Dual-Energy X-ray Absorptiometry (DXA) in Men 44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men 45. Advanced Structural Assessment of Bone Using CT and MRI 46. Vertebral Fracture Assessments 47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis 48. Overall diagnostic strategy

Section 10 Therapy 49. Diagnostic Thresholds for Osteoporosis in Men 50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges 51. Nutritional Therapy for Skeletal Health in Men 52. Exercise Programs for Patients with Osteoporosis 53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications 54. Treatment of Male Osteoporosis with Bisphosphonates 55. Treatment of Male Osteoporosis with Parathyroid Hormone 56. Testosterone Therapy for Osteoporosis in Men 57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon

O autorze

Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium