Organic Cation Transporters: Integration of Physiology, Pathology, and Pharmacology

ISBN-13: 9783319795348 / Angielski / Miękka / 2019 / 264 str.

Giuliano Ciarimboli;Sophie Gautron;Eberhard Schlatter

Opis

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Recenzje

"This encyclopedic resource provides extensively detailed, state-of-the-art information about cellular organic cation transporters and their relevance to human function and disease. ... This is a magnificent resource for scientists actively engaged in any research related to the biology of organic ion transporters. Every conceivable topic related to these transporters is addressed, making it useful for active researchers in a wide variety of biomedical and biological disciplines." (David R. Bell, Doody's Book Reviews, April, 2016)

Spis treści

Introduction to the cellular transport of organic cations.- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism.- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity.- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy.- Physiological and pathological regulation of transporters for organic cations.- Endocrine and metabolic regulation of transporters for organic cations.- Organic cation transporters (OCTs) as modulators of behavior and mood.- Organic cation transporters as modulators of neurodegeneration and neuroprotection.- Translational relevance of animal models for the study of organic cation transporter function.- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.