Organelle and Molecular Targeting

ISBN-13: 9780367551377 / Angielski / Twarda / 2021 / 488 str.

Lara Scheherazade Milane; Mansoor M. Amiji

Opis

Drugs must be delivered to the target tissue or, better yet, the target organelles. A more specific target minimizes toxicity and side effects and maximizes therapeutic effect. This book is a comprehensive review of Organelle Targeting.

Spis treści

Preface. Acknowledgments. Editors. Contributors. SECTION ONE: INTRODUCTION: ORGAN, TISSUE, AND CELLULAR LOCALIZATION. Route of Administration, Distribution, and Tissue-Specific Challenges. Nanomedicine and Drug Delivery Approaches. Escaping Immune Clearance. Passive Drug Delivery, Mechanisms of Uptake, and Intracellular Trafficking. Tumor Targeting. Localizing Therapeutics to the Brain. Pulmonary Drug Delivery. Cardiovascular Drug Delivery. Localizing Therapeutics to the Gastrointestinal System. Targeting Immune Cells and Dysfunction. SECTION TWO: OVERCOMING CELLULAR BARRIERS. Overcoming the Plasma Membrane. Overcoming the Mucus Barrier. Directing Therapies to Lysosomes. Microtubule Targeting in Cancer Treatment. Localizing Therapeutics to the Endoplasmic Reticulum. Targeting Mitochondria. Directed Therapies to Nucleic Acid and Cytoplasmic RNA. Considerations for Engineering Nanoparticles for Achieving Subcellular Organelle Targeting. Index.