Oral Tolerance in Transplantation

ISBN-13: 9783639222463 / Angielski / Miękka / 2010 / 160 str.

Juan Zhou

Opis

A major goal of transplantation research is to develop a specific immune unresponsiveness to alloantigen. Oral administration of antigen prior to systemic challenge has been demonstrated to suppress systemic immune responses, and this antigen specific suppression is termed oral tolerance. This book assesses whether oral tolerance can be used to prolong kidney allograft survival and investigates the mechanisms by which this survival is prolonged. The book described that oral exposure to alloantigen prolongs kidney allograft survival in rats in an allospecific manner. The prolongation is due to a generation of CD8+ T regulatory (Treg) cells in the recipient. The CD8+ Treg cells are present in the spleen, mesenteric lymph nodes and kidney allograft and able to transfer the graft prolongation to naïve recipient. These Treg cells may shift immune responses towards type 2 responses and delete alloreactive T lymphocytes through Fas/FasL interaction.

O autorze

Juan Zhou was born in Xi an, China. She obtained a M.D. and practiced as an ophthalmologist in China. Since immigrated to Canada, she earned a M.Sc. in biology and a Ph.D. in Immunology from Dalhousie University. She is currently an Assistant Professor in Dalhousie University and her main research interest is transplantation tolerance.