Oral Delivery of Insulin

ISBN-13: 9781907568473 / Angielski / Twarda / 2014 / 290 str.

T A Sonia

Opis

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

• Presents an overview of Diabetes Mellitus
• Includes a discussion of various strategies and techniques adopted for oral delivery of insulin
• Presents an update of research in the field

Recenzje

"...a comprehensive account of the status of oral insulin delivery...any scientist beginning work in the field should read their book." --International Journal of Pharmaceutics

Spis treści

• List of figures and tables
  • Figures
  • Tables
• About the authors
• 1: Diabetes mellitus - an overview
  • Abstract
  • 1.1 Diabetes mellitus - an introduction
  • 1.2 Glucose homeostasis
  • 1.3 Types of diabetes
  • 1.4 Symptoms of diabetes
  • 1.5 Complications of diabetes
  • 1.6 Diagnosis of diabetes mellitus
  • 1.7 Therapy for diabetes
  • 1.8 Non-insulin treatment options of type 1 diabetes
  • 1.9 Treatment options of type 2 diabetes
  • 1.10 Conclusion
• 2: Routes of administration of insulin
  • Abstract
  • 2.1 Current approach for the delivery of insulin
  • 2.2 Routes of administration of insulin
  • 2.3 Conclusion
• 3: Oral insulin delivery - challenges and strategies
  • Abstract
  • 3.1 Oral delivery of insulin
  • 3.2 Barriers to oral delivery of insulin
  • 3.3 Strategies and alternatives to improve oral insulin delivery
  • 3.4 Conclusion
• 4: Experimental techniques involved in the development of oral insulin carriers
  • Abstract
  • 4.1 Introduction
  • 4.2 Polymeric nanoparticles
  • 4.3 Physicochemical characterization of nanoparticles
  • 4.4 Biological evaluation
  • 4.5 In vitro method for assessing drug permeability
  • 4.6 In vivo study of oral insulin
  • 4.7 Biodistribution studies
  • 4.8 Conclusion
• 5: Lipids and inorganic nanoparticles in oral insulin delivery
  • Abstract
  • 5.1 Lipid-based systems for oral delivery of insulin
  • 5.2 Liposomes
  • 5.3 Solid lipid nanoparticles
  • 5.4 Nanostructured lipid carriers
  • 5.5 Niosomes
  • 5.6 Archaeosomes
  • 5.7 Cubic nanoparticles (cubosomes)
  • 5.8 Aquasomes
  • 5.9 Inorganic nanoparticles as carriers for oral insulin delivery
  • 5.10 Conclusion
• 6: Polymers in oral insulin delivery
  • Abstract
  • 6.1 Introduction
  • 6.2 Characteristics of an ideal oral insulin carrier
  • 6.3 Polymers in oral insulin delivery
  • 6.4 Natural polymers
  • 6.5 Synthetic polymers
  • 6.6 Conclusion
• 7: Summary and future perspectives for oral insulin delivery
  • Abstract
  • 7.1 Introduction
  • 7.2 Technologies developed for clinical applications of oral insulin delivery
  • 7.3 Conclusions and future perspectives
• Index

O autorze

T. A. Sonia is a doctoral student working in the field of development of polymeric nano/micro particles for oral delivery of insulin under the guidance of Dr Chandra P Sharma at Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India. She completed her graduate studies in Polymer Science from School of Chemical Sciences, Mahatma Gandhi University, Kerala, India. Dr. Chandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018).