Optimization of Aerosol Drug Delivery

ISBN-13: 9789048164363 / Angielski / Miękka / 2010 / 315 str.

Leon Gradon; J. C. Marijnissen

Opis

Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy.
The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined.
The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.

Spis treści

Introduction A history of the development of therapy by jet nebulisation; Ola Nerbrink Molecular modelling in drug design; Bogdan Lesyng and Witold Rudnicki Particle elaboration using supercritical media for drug delivery into the human lungs; Jerzy Baldyga and Marek Henczka Electrospray as means to produce monodisperse drug particles; Kees Geerse and Jan Marijnissen Optimization of dry powder aerosols for systemic drug delivery; Rita Vanbever Recent advances in drug delivery via pressurised metered-dose inhalers; John Pritchard Resuspension of powders and deposition of aerosol particles in the upper human airways; Leon Gradon, Tomasz Sosnowski and Arkadiusz Moskal Transport and deposition of hydrophilic drug particles in the lungs; Joachirn Heyder, Josef Gebhart, Christa Roth and George Ferron Ventilation modelling and drug deposition in very young asthmatic children; Frans de Jongh and Rupino Griffioen Modeling aerosol drug delivery; Yung Sung Cheng Application of electro hydro dynamic atomisation in the production of engineered drug particles; Tomasz Ciach, Lidia Diaz, Esther van den IJssel and Jan Marijnissen Interaction of deposited aerosol particles with the alveolar liquid layer; Tomasz Sosnowski, Leon Gradon, Ferry Iskandar and Kikuo Okuyama Pulmonary deposition and effects of aerosolized drugs in pulmonary patients; Eric Derom Targetting aerosols to disease areas; Pieter Zanen Treatment of asthma patients under severe conditions; Giuseppe Marraro Understanding the mechanisms of local pulmonary drug absorption and metabolism: An in vitro model of the airway epithelium; Gerrit Borchard Overview; Gerrit Borchard Keyword Index List of Authors