Preface; Acknowledgements; 1. Frontiers in device engineering Philip Seliger and A. F. J. Levi; 2. Atoms-up design Stephan Haas; 3. Electron devices and electron transport K. Magruder, Philip Seliger, and A. F. J. Levi; 4. Aperiodic dielectric design Philip Seliger; 5. Design at the classical-quantum boundary Rodrigo Muniz and Stephan Haas; 6. Robust optimization in high dimensions Omid Nohadani and Dimitris Bertsimas; 7. Mathematical framework for optimal design I. G. Rosen and C. Wang; 8. Future directions A. F. J. Levi; Appendix A; About the authors; Index.