Part I. Substance Use Disorders in Women and Pregnancy: 1. The opioid epidemic and pregnant women Tricia E. Wright; 2. Screening, brief intervention and referral to treatment for opioid use disorders in pregnancy Tricia E. Wright; 3. Substance use assessment during pregnancy Jacqueline Starrer and Carl Christenson; 4. Co-occurring mental health conditions in pregnant women with opioid use disorders Alexis S. Hammond and Margaret S. Chisolm; 5. Trauma and post-traumatic stress disorder in women with opioid use disorder in pregnancy Soraya Asadi; 6. Intimate partner violence, pregnancy and substance use disorder Rich Soper and Hendree Jones; 7. Medical comorbidities in women with opioid-use disorders in pregnancy Kaylin A. Klie; 8. Harm reduction principles in women with opioid use disorder in pregnancy Lauren Owens and Mishka Terplan; Part II. Antepartum and Intrapartum Care: 9. Prenatal care in substance-using pregnant women Charles Schauberger; 10. Treatment approaches in women with substance use disorders who become pregnant Hendree Jones; 11. Medication assisted treatment for opioid use disorder during pregnancy Lawrence Leeman and Jacqueline Starer; 12. Labor and delivery management in women with substance use disorder Marjorie Meyer and Tricia Wright; Part III. Postpartum: 13. Postpartum care for women with substance use disorders Elizabeth E. Krans, Sebastian T. Tong and Mishka Terplan; Part IV. The Newborn: 14. Neonatal abstinence syndrome Karol Kaltenbach and Loretta Finnegan; 15. Breastfeeding and the substance-exposed dyad Lauren M. Jansson and Stephen W. Patrick.