Observer Performance Methods for Diagnostic Imaging: Foundations, Modeling, and Applications with R-Based Examples

ISBN-13: 9780367781637 / Angielski / Miękka / 2021 / 542 str.

Dev P. Chakraborty

Opis

This book provides a complete, introductory overview of this growing field and its applications in medical imaging, utilizing worked examples and exercises to demystify statistics for readers of any background. It covers discussion of study design basics and use of the techniques in imaging system optimization, among other topics.

Spis treści

1 Preliminaries

PART A The receiver operating characteristic (ROC) paradigm

2 The binary paradigm

3 Modeling the binary task

4 The ratings paradigm

5 Empirical AUC

6 Binormal model

7 Sources of variability in AUC

PART B Two significance testing methods for the ROC paradigm

8 Hypothesis testing

9 Dorfman–Berbaum–Metz–Hillis (DBMH) analysis

10 Obuchowski–Rockette–Hillis (ORH) analysis

11 Sample size estimation

PART C The free-response ROC (FROC) paradigm

12 The FROC paradigm

13 Empirical operating characteristics possible with FROC data

14 Computation and meanings of empirical FROC FOM-statistics and AUC measures

15 Visual search paradigms

16 The radiological search model (RSM)

17 Predictions of the RSM

18 Analyzing FROC data

19 Fitting RSM to FROC/ROC data and key findings

PART D Selected advanced topics

20 Proper ROC models

21 The bivariate binormal model

22 Evaluating standalone CAD versus radiologists

23 Validating CAD analysis

O autorze

Dev P. Chakraborty received his PhD in physics in 1977 from the University of Rochester, NY. Following postdoctoral fellowships at the University of Pennsylvania (UPENN) and the University of Alabama at Birmingham (UAB), since 1982 he has worked as a clinical diagnostic imaging physicist. He is American Board of Radiology certified in Diagnostic Radiological Physics and Medical Nuclear Physics (1987). He has held faculty positions at UAB (1982 - 1988), UPENN (1988-2002) and the University of Pittsburgh (2002-2016). At UPENN he supervised hospital imaging equipment quality control, resident physics instruction and conducted independent research. He is an author on 78 peer-reviewed publications, the majority of which are first-authored. He has received research funding from the Whittaker Foundation, the Office of Women's Health, the FDA, the DOD, and has served as principal investigator on several NIH RO1 grants.