Nutrition in Epigenetics

ISBN-13: 9780813816050 / Angielski / Twarda / 2011 / 384 str.

Mihai D. Niculescu

Opis

The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Spis treści

Contributors.

1. Introduction (Mihai D. Niculescu and Paul Haggarty).

PART I: Fundamental Principles in Epigenetics.

SECTION A: Epigenetic Mechanisms.

2. DNA Methylation (Natalia V. Cucu).

3. Chromatin Modifications (Sandra B. Hake).

4. Roles of RNAi and Other MicroRNAs in the Regulation of Epigenetic Processes (Muller Fabbri).

5. Epigenetic Inheritance: Both Mitotic and Meiotic (Nina J. Kaminen–Ahola, Arttu I. Ahola, and Emma Whitelaw).

SECTION B: Development Epigenetics.

6. Developmental Epigenetics: Roles in Embryonic Development (Liliana Burliba a and Lucian Gavril ).

SECTION C: Epigenetic Mechanisms in Disease.

7. Epigenetics, Nutrition, and Cancer (Amy R. Johnson).

8. Metabolic Syndrome, Obesity, and Diabetes (Karen D. Corbin).

9. Autoimmunity (Donna Ray and Raymond Yung).

10. Cardiovascular Diseases (Aurelian Bidulescu and Methode Bacanamwo).

PART II: Nutritional Status and Specific Nutrients.

SECTION A: Maternal Nutrition and Fetal Development.

11. Maternal Nutrition and Developmental Outcomes (Shannon L. Haley, Laurie J. Moyer–Mileur, Robert H. Lane, and Lisa A. Joss–Moore).

SECTION B: Role of Specific Nutrients.

12. Folate, Vitamin B12, and Vitamin B6 (Patrick J. Stover).

13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development (Steven H. Zeisel).

14. Epigenetic Regulation by Retinoids (Amandio Vieira).

15. We are WhatWe Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome (Carlos M. Guerrero–Bosagna and Susan J. Clark).

16. Isothiocyanates and Polyphenols (Nigel J. Belshaw and Ian T. Johnson).

SECTION C: Macronutrient Intakes.

17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation (Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge).

SECTION D: Environmental Exposures.

18. Epigenetic Manifestation of Environmental Exposures (Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek).

SECTION E: Epidemiology of Nutritional Epigenetics.

19. Epigenetics, Nutrition, and Reproduction: Short– and Long–Term Consequences (Paul Haggarty).

20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective (Audrey Jung and Ellen Kampman).

Index.

O autorze

Mihai D. Niculescu is an Assistant Professor of Nutrition at the University of North Carolina s Gillings School of Global Public Health in Chapel Hill, and at the UNC Nutrition Research Institute in Kannapolis, North Carolina, USA.

Paul Haggarty is Head of the Lifelong Health Programme, and the Nutrition and Epigenetics Group, at the Rowett Institute of Nutrition and Health in the University of Aberdeen in Aberdeen, Scotland.