Nuclear Factor кb: Regulation and Role in Disease

ISBN-13: 9789401039833 / Angielski / Miękka / 2012 / 426 str.

Rudi Beyaert

Opis

The transcription factor NF-kappaB and the signaling pathways regulating its activity constitute a paradigm of membrane to nucleus communication. NF-kappaB is central to a number of cellular functions including cell proliferation, apoptosis, and cellular differentiation. This transcription factor also plays essential roles in innate and acquired immunity, and its deregulation leads to important human diseases such as inflammation and cancer. Therefore NF-kappaB, together with the signaling pathways leading to its activation, constitute an attractive therapeutic target. This book is the first to review and synthesize our knowledge on this interesting transcription factor. It will be of great interest for those entering or already actively working in the NF-kappaB field, as well as a valuable reference for students, established researchers, or clinicians with wider interests in the fields of molecular cell biology and biomedicine.

Spis treści

Contributors. Preface. Activators and Target Genes of Rel/NF-kappaB Transcription Factors - From Bench to Bedside; T. Loop, H.L. Pahl. NF-kappaB Activation by Tumor Necrosis Factor and Interleukin-1; I. Carpentier, S. Janssens, K. Heyninck, R. Beyaert. NF-kappaB Activation by CARD Proteins; J.-L. Poyet, E.S. Alnemri. Viruses as Intruders in the Rel/NF-kappaB Signaling Pathway; T.D. Gilmore, G. Mosialos. The IkappaB Kinase (IKK) Complex; U. Senftleben, M. Karin. The Role of Ubiquitin in NF-kappaB Signaling; L. Deng, Z.J. Chen. New Insights into the Regulation of NF-kappaB - Roles for Phosphorylation and Acetylation of NF-kappaB Subunits; A. O'Mahony, L.F. Chen, W.C. Greene. The Structural Biology of NF-kappaB; T. Huxford, G. Ghosh. Tools to Interfere with NF-kappaB Activation; Y. Yamamoto, U.N. Verma, R.B. Gaynor. Regulation of NF-kappaB by Glucocorticoids; K. De Bosscher, W. Vanden Berghe, G. Haegeman. Genetic Analysis of NF-kappaB-dependent Signaling Pathways in Mammalian Cells; X. Li, G.R. Stark. Delineation of NF-kappaB Signaling by Gene Targeting; N. Suzuki, M. Bonnard, S. Suzuki, W.-C. Yeh. The Role of NF-kappaB in Inflammatory Diseases; E. Andreakos, I. Udalova, S. Sacre, B.M. Foxwell. NF-kappaB in Genetic Disorders; G. Courtois, A. Israël. NF-kappaB in the Vascular System; R. De Martin. NF-kappaB in T-lymphocyte Biology; O. Dienz, S. Bacher, M.L. Schmitz. NF-kappaB in the Nervous System; B. Kaltschmidt, C. Kaltschmidt. NF-kappaB in Oncogenesis and as a Target for Cancer Therapy; A.S. Baldwin Jr. Control of Immunity by Rel Proteins in Drosophila; P. Georgel. Index.