Novel Cytokine Inhibitors

ISBN-13: 9783764359423 / Angielski / Twarda / 2000 / 400 str.

G.A. Higgs;B. Henderson;M. J. Parnham

Opis

This book reviews recent advances in the development of new anti-infla mmatory drugs. It addresses different therapeutic intervention possibi lities for new drugs, such as the cellular source of cytokines, specif ic receptors that induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signaling pathways from these recep tors. Accordingly, experts were drawn from different backgrounds, incl uding academic research institutes, the pharmaceutical industry and cl inical pharmacology. In each area, the opportunities for drug developm ent are highlighted and, where possible, clinical data is reviewed.

Spis treści

Contents. List of Contributors. Brian Henderson and Gerry Higgs: Targets
for modulating cytokine responses in inflammatory and infectious
diseases. Mary Lee MacKichan and Anthony L. DeFranco: Cell signalling
and cytokine induction by lipopolysaccharide. Rodger A. Allen and
Stephen E. Rapecki: Regulation of cytokine production by inhibitors of
cell signalling. Stanley T. Crooke: Oligonucleotide-based drugs in the
control of cytokine synthesis. Peter I. Croucher, Ingunn Holen and
Philip G. Hargreaves: Inhibiting cytokine-processing enzymes. Amanda
Suitters and Roly Foulkes: Cytokine-neutralizing therapeutic antibodies.
Ravinder N. Maini: The debut of anti-TNF therapy of rheumatoid arthritis
in the clinic. Anthony Meager: Blockade of cytokine activity by soluble
cytokine receptors. Michael F. Smith Jr.: Interleukin-1 receptor
antagonist. Raymond J. Owens and Simon Lumb: Therapeutic regulation of
cytokine signalling by inhibitors of p38 mitogen-activated protein
kinase. Christian Bogdan, Yoram Vodovotz and John Letterio: TGF-ß and
IL-10: inhibitory cytokines regulating immunity and the response to
infection. Brian Henderson: Therapeutic control of cytokines: lessons
from microorganisms. Index