Novel Antimalarial Drugs : Study of Amino-quinoline Mannich Bases

ISBN-13: 9783659253713 / Angielski / Miękka / 2012 / 80 str.

Bhupendra Singh; Dipak Chetia

Opis

Development of resistance has severely limited the choice of available antimalarial drugs, which clearly highlights the urgent need of novel chemotherapeutic agents for the treatment of malaria. The purpose of this study was to develop new potential antimalarial agents with Amino-quinoline ring. A series of novel Amino-quinoline Mannich base drug molecules have been synthesized.The synthesized molecules were evaluated for in vitro and in vivo antimalarial activity against the chloroquine sensitive 3D7 (West Africa) and RKL-2 strain of Plasmodium falciparum and rodent malaria parasite Plasmodium yoelii (strain N-67) in Swiss mice model.

O autorze

Bhupendra Singh is a Asst. Professor in Pharm. Chemistry. He is working in the S. N. Medical College, Agra (India). He has authored more than 7 research publications in various journals of national and international repute. He is a Fellow of the Institute of Chemist (India), he is also life member(s) of various professional bodies like IPA,APTI.