Non-Steroidal Anti-Inflammatory Drugs Basis for Variability in Response: 16-18 May, 1985, at Leura, New South Wales, Australia

ISBN-13: 9783764317508 / Angielski / Miękka / 1985 / 203 str.

Brooks;Day; Peter Brooks

Opis

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs in the community. This reflects the high frequency of rheumatic complaints but may in part be due to the relative non efficacy of these drugs. Since the introduction of ibuprofen, the first new NSAID to compete with aspirin, phenylbutazone and indomethacin, there has been a proliferation of new NSAIDs of differing chemical classes but an apparent similar spectrum of action. Despite the fact that these drugs are thought to work by an apparent common mechanism of action (suppression of prostaglandin synthetase activity) continued development of these drugs occurs. There exists at present a conflict between the pharmaceutical industry with its attempts to introduce new NSAIDs and drug regulatory authorities who are generally not convinced of the need for additional drugs of_ this class. The practising clinician regards a variety of NSAIDs as necessary to enable pain relief to be optimised.with minimal adverse effects. With respect to the dilemma of how many NSAIDs are really necessary surprisingly little convincing data is available to assist in resolving this issue. It was therefore decided to hold a satellite meeting to the XVIth International League Against Rheumatism Conference in May 1985.

Spis treści

Variability in Response to NSAIDs.- Variance in NSAID Studies: Contribution of Patient Variance.- Patient Preference Scales.- Variation in Physician Assessment of Response to Treatment.- Community Surveillance Study — Perceived Response of Rheumatoid Arthritis Patients to NSAIDs.- Impact of over the Counter Availability of Non-Steroidal Anti-Inflammatory Drugs.- Pharmacokinetic Factors as Causes of Variability in Response to Non-Steroidal Anti-Inflammatory Drugs.- Synovial Fluid Kinetics of Non-Steroidal Anti-Inflammatory Drugs.- The Importance of Unbound Drug.- The Effect of Renal Dysfunction on the Disposition of Non-Steroidal Anti-Inflammatory Drugs Forming Acyl Glucuronides.- NSAIDs — Interaction with Anti-Hypertensives and Diuretics.- Aspects of the Effects of NSAIDS on Renal Function in Congestive Heart Failure.- The Relationship between Non-Steroidal Anti-Inflammatory Drugs, the Development of Peptic Ulcer and Its Complications — Can We Estimate Risk.- Stereo Selective Disposition — Basis for Variability in Response to NSAIDs.- Postulated Reactive Intermediates of NSAIDs.- Pharmacokinetics of Non-Steroidal Anti-Inflammatory Drugs in the Elderly.- Significance of NSAID Serum to Response Relationships.- The Relationship between the Plasma Concentration of Non-Steroidal Anti-Inflammatory Drugs and Their Therapeutic Effect.- NSAID Plasma Concentration Monitoring — Optimising Treatment of RA.- Problems with Demonstrating NSAID Concentration Response Relationships.- Overlap Between Non-Steroidal Anti-Inflammatory Drugs and Anti-Rheumatoid Drugs.- Reactive Oxygen Species and Drug Therapy for Inflammatory Diseases.- Effects of Diclofenac Sodium on Arachidonic Acid Metabolism.- The Effects of Voltaren on Arachidonic Acid Metabolism in Arthritis Patients.