Non-Ionic Surfactant Vesicles for Ophthalmic Drug Delivery

ISBN-13: 9783846589571 / Angielski / Miękka / 2013 / 96 str.

Rastogi Bhavya;Nagaich Upendra;Jain D a

Opis

Niosomes was developed and characterized for ocular drug delivery of diclofenac potassium. The present research study is a promising approach to improve corneal penetration and bio availability characteristics. Formulation also found to ensure a good entrapment efficiency and ocular bio availability of drug in-vivo. Niosome containing diclofenac potassium were prepared using surfactant and cholesterol in different ratio by Lipid film hydration technique. Niosomes were characterized For Entrapment efficiency, Particle size analysis, In-vitro drug release and In-vivo studies. Formulation with low cholesterol content which shown 82.1% Entrapment efficiency, 70.01% sustained release over a period of 10 h followed a non-fickian profile with zero order release profile. Scanning electron micrograph indicated that niosomes have a discrete spherical structure without aggregation. In-vivo study showed an availability of drug in aqueous humor for an extended time period even up to 8 hour and it showed a correlation with the release profile in-vitro. Niosome are considered the best as it showed good and high Entrapment efficiency and Vitro release with better bio availability.

O autorze

Mr. Bhavya Rastogi is currently working as Assistant Professor of Pharmaceutics in School of Pharmacy, Bharat Institute of Technology (BIT), Meerut (U.P.) India. He is associated with Society of Pharmaceutical Education & Research (SPER). He is Section Editor ofPharmaceutics section of SPER Times. He is well engaged in various research activities.