Nmr: Principles and Applications to Biomedical Research

ISBN-13: 9781461279570 / Angielski / Miękka / 2011 / 618 str.

Jay W. Pettegrew

Opis

Nuclear magnetic resonance (NMR) is having an enormous liTIpact on biomedical research both at the basic science and clinical levels. In order to appreciate the elegance and power of this technology a historical perspective is in order. In 1924 Pauli suggested that hydrogen nuclei might possess a magnetic IIlOlllent. This was in fact confinned by Rabbi in 1939 who demonstrated that a beam of hydrogen molecules in the presence of a magnetic field could be mutated by radio frequency fields resonating at the Iarmor frequency. 'Ihe first successful NMR experiments in condensed matter were independently conducted in late 1945 by Purcell, Torrey and PoUnd and by Bloch, Hansen and Packard. 'Ihe Purcell group detected proton NMR in solid paraffin and the Bloch group detected proton in liquid water. Bloch and Purcell received the Nobel Prize in physics in 1952 for these observations . Until about 1952, studies of liquids and solids with broad resonance lines dominated the field of NMR. However, the reports of 3 1 P NMR chemical shifts in several corrpounds in 1949 by Khight, of 14 N resonances in several ions by Proctor and Yu in 1950, and of 1 9 F resonances in several corrpounds in 1950 by Dickinson led to the development of high resolution NMR in Itquids. since the molecular motions in liquids result in very narrow lines compared to those in solids: much smaller chemical shifts could be detected.

Spis treści

Principles of Pulse NMR Spectroscopy.- Relaxation Theory with Applications to Biological Studies.- Two-Dimensional Fourier Transform NMR: Homonuclear and Heteronuclear Couplings - Multiple Quantum Filtering.- High-Resolution NMR of Solids.- Artificial Intelligence Techniques and NMR Spectroscopy: Application to the Structure of Proteins in Solution.- Application of Solid State NMR to the Lipids of Model and Biological Membranes.- Application of 31P NMR to Eye Research.- 31P NMR of Brain Aging and Alzheimer’s Disease.- NMR Spectroscopy of Tumors.- Solid State 31P and 27Al NMR Studies of Model Membranes and Mammalian Brain: Possible Implications for Alzheimers Disease.- 23Na and 7Li NMR Studies of Mammalian Cells: Assessment of Cation Transport and Cytoskeletal Structure with Application to Manic Depressive Disease.- Theory and Technique of Surface Coils in In Vivo Spectroscopy.- 31P In Vivo Spectroscopy of Mult Human Brain.- 1H-NMR Spectroscopy of Brain.- Nuclear Magnetic Resonance and Cell pH With a Focus on Brain pH.- to NMR Imaging.- NMR Imaging: Techniques and Developments.- Contrast Media for MRI: Present and Future Applications.- NMR Imaging of the Human Brain — Insists into Neurological Diseases.- Magnetic Resonance Imaging in Psychiatry.